Results 281 to 290 of about 273,066 (341)

New cell lines expanding the diversity of Ewing sarcoma models

International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.
What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff, Christiane Schaefer, Wilhelm G. Dirks, Dawid Krzeciesa, Maximilian Bretschneider, Pauline R. Plaumann, Wiebke K. Guder, Arne Streitbürger, Sonja Herter, Heike Peterziel, Ina Oehme, Felina Zahnow, Thomas G. P. Grünewald, Uta Dirksen   +13 more
wiley   +1 more source

Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus

Glia, Volume 74, Issue 1, January 2026.
In Vrk2‐deficient mice, tonic GABA inhibition is reduced in the mediodorsal thalamus due to impaired astrocytic GABA synthesis. Microglial VRK2 regulates this process via TNF‐α signaling, revealing a glial–glial mechanism of thalamic inhibition.
Dongsu Lee, Go Eun Ha, Yeleen Lee, Denise Lee, Jongseo Lee, Jae Ho Yoon, Leechung Chang, Kyung Won Jo, Ho‐Keun Kwon, Kyong‐Tai Kim, Eunji Cheong   +10 more
wiley   +1 more source

Detection of Gastric Cancer Micrometastases in Lymph Nodes by Amplification of Keratin 19 mRNA with Reverse Transcriptase‐Polymerase Chain Reaction

, 1996
Sbinzaburo Noguchi, M Hiratsuka, Hiroshi Furukawa, Tomohiko Aihara, Tsutomu Kasugai, Sumihito Tamura, Shingi Imaoka, Hiroki Koyama, Takeshi Iwanaga   +8 more
openalex   +2 more sources

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Dengue Fever and Its Burden in Burkina Faso: An Overview

Reviews in Medical Virology, Volume 36, Issue 1, January 2026.
ABSTRACT Dengue fever is an arbovirus disease caused by the dengue virus and has been diagnosed in Burkina Faso for many years. In recent decades, the disease has become a growing concern, thereby impacting the public health system. Several factors contribute to the pathogenesis of dengue fever, including the immune system and the virulence of ...
Wendimi Fatimata Belem, Ibrahim Sangare, Caroline Gilbert, Wilfried Wenceslas Bazié   +3 more
wiley   +1 more source

Development and Validation of Multivariable Machine‐Learning Models for the Prediction of Multisystemic Inflammatory Syndrome Outcomes in Latin American Children

Acta Paediatrica, Volume 115, Issue 1, Page 133-145, January 2026.
ABSTRACT Aim We aimed to develop and test machine learning algorithms for the prediction of severe outcomes associated with MIS‐C. Method An observational ambispective cohort study was conducted including children aged from 1 month to 18 years old in 84 hospitals from the REKAMLATINA (Red de la Enfermedad de Kawasaki en America Latina) network ...
Danilo Buonsenso, Luca Mastrantoni, Rolando Ulloa‐Gutierrez, Jimena García‐Silva, Gabriela Ivankovich‐Escoto, Marco A. Yamazaki‐Nakashimada, Enrique Faugier‐Fuentes, Olguita del Águila, German Camacho‐Moreno, Dora Estripeaut, Iván F. Gutiérrez‐Tobar, Adriana H. Tremoulet, The REKAMLATINA‐3 MIS‐C Study Group Investigators   +12 more
wiley   +1 more source

Nitro‐oleic acid activation of endothelial PPARγ signaling pathway alleviates neurovascular injury and improves functional outcomes in ischemic stroke

Brain Pathology, Volume 36, Issue 1, January 2026.
OA‐NO2 activation of endothelial PPARγ signaling pathway alleviates ischemic brain injury. Endothelial OA‐NO2‐PPARγ signaling pathways preserve BBB integrity, reduce peripheral inflammatory cell infiltration, and improve functional outcomes after ischemic stroke.
Tianqing Xiong, Na Qiu, Andrew Ni, Xiaotao Xu, Ping Sun, Shun Li, Ke‐Jie Yin   +6 more
wiley   +1 more source

Efficacy of a Combined Natural Extract of Turmeric (Curcuma longa) and Liquorice (Glycyrrhiza uralensis) Against Viral Haemorrhagic Septicaemia Virus in Olive Flounders (Paralichthys olivaceus)

Journal of Fish Diseases, Volume 49, Issue 1, January 2026.
ABSTRACT Viral haemorrhagic septicaemia virus (VHSV) causes a high mortality rate in cultured olive flounder, and effective treatment for VHSV infection is urgently required. Turmeric (Curcuma longa ) and liquorice (Glycyrrhiza uralensis) are well‐known medicinal plants with a variety of biological activities. Turmeric and liquorice extract combination
Su‐Mi Shin, Walimuni Randika Harshan Mendis, So Young Kang, Hyung Jae Jeong, Taeho Kim, Sung‐Ju Jung   +5 more
wiley   +1 more source

Ras Homolog Enriched in Brain Protein Reverses Amyloid Beta‐Induced Escape of Inflammatory Cytokine mRNAs From Immunoisolated RNA Processing Bodies of Glioblastoma Cells

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
A detergent‐based method, combined with immunoprecipitation using an anti‐P‐body component‐specific antibody, was used to isolate RNAs associated with RNA processing bodies (PBs) from both neuronal and glial cells. In neurons, β‐amyloid oligomers helped to trap specific mRNAs related to neuronal differentiation into PBs.
Sritama Ray, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, Volume 15, Issue 12, Page 2031-2044, December 2025.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source