Results 291 to 300 of about 266,159 (347)

Transcriptional gene fusions via targeted integration at safe harbors for high transgene expression in Chlamydomonas reinhardtii

New Phytologist, EarlyView.
Summary Conventional genetic engineering in green microalgae employs error‐prone nonhomologous end joining to integrate recombinant DNA at double‐strand breaks generated at random positions across the nuclear genome. This typically results in variable transcription strength and requires a labor‐intensive screening procedure to identify transformants ...
Nick Jacobebbinghaus, Florian Bigge, Merve Saudhof, Wolfgang Hübner, Olaf Kruse, Thomas Baier   +5 more
wiley   +1 more source

Aphid effector Mp10 balances immune suppression and defence activation through EDS1‐dependent modulation of plant DAMP responses

New Phytologist, EarlyView.
Summary Damage‐associated molecular pattern (DAMP)‐triggered immunity (DTI) serves as a crucial first line of defence against aphid attack, yet how aphids manage this response remains unclear. By investigating the colonisation of Arabidopsis thaliana by the highly polyphagous peach–potato aphid (Myzus persicae), we identified cell wall‐derived DAMPs ...
Matteo Gravino, Sam T. Mugford, Daniela Pontiggia, Joshua Joyce, Claire Drurey, David C. Prince, Felice Cervone, Giulia De Lorenzo, Saskia A. Hogenhout   +8 more
wiley   +1 more source

The Role of Vimentin 3 in Ameloblastomas: A Novel Tumor Biomarker

Oral Diseases, EarlyView.
ABSTRACT Introduction Ameloblastoma (ABL), a common odontogenic tumor in the maxillofacial region, presents primarily as unicystic (U‐ABL) and conventional (C‐ABL) variants. Despite shared epithelial features, their distinct biological behaviors may stem from interactions between connective tissue and epithelial cells.
Sibel Elif Gultekin, Melanie von Brandenstein, Emre Baris, Ipek Atak Secen, Leyla Arslan Bozdag, Heike Goebel   +5 more
wiley   +1 more source

Circulating Cell‐Free DNA Concentration as a Biomarker in Head and Neck Cancer

Oral Diseases, EarlyView.
ABSTRACT Objective Head and neck squamous cell carcinoma (HNSCC), particularly human papillomavirus (HPV) ‐negative HNSCC, poses a significant clinical challenge due to late diagnoses and poor survival. This study evaluates the potential of circulating cell‐free DNA (ccfDNA) as a minimally invasive biomarker for diagnosis, prognosis and disease ...
Ana María Rodríguez‐Ces, Óscar Rapado‐González, Santiago Aguín‐Losada, Inés Formoso‐García, José Luís López‐Cedrún, Gabriel Triana‐Martínez, Rafael López‐López, María Mercedes Suárez‐Cunqueiro   +7 more
wiley   +1 more source

RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy‐mediated degradation of the viral silencing suppressor P6 protein

Plant Biotechnology Journal, EarlyView.
Summary Responsive to desiccation 21 (RD21) is a papain‐like cysteine protease (PLCP). PLCPs are involved in plant growth and development, as well as stress and plant immune responses. Currently, few studies have reported on the involvement of PLCPs in defence against viral infections.
Xianchu Yang, Jiying Feng, Kai Xu, Jincheng Han, Minghui Zhang, Aiwen Cheng, Zhanqi Wang, Fang Wang, Xueping Zhou, Lei Jiang, Tong Jiang   +10 more
wiley   +1 more source

Seamless, modular binary vectors for plant cell and molecular biology

Plant Biotechnology Journal, EarlyView.
Summary In plants, genetic manipulations are commonly performed using Agrobacterium tumefaciens, a plant pathogen whose abilities as a ‘natural genetic engineer’ have been co‐opted for biotechnological applications. In the widely used binary vector systems, Agrobacterium already contains a plasmid with most of the genes needed for virulence and is ...
Rory Greenhalgh, Wilson Horner, Katherine A. Klimpel, Snigdha Chatterjee, M. Regina Scarpin, Jacob O. Brunkard   +5 more
wiley   +1 more source

The Module WmABF1‐1‐WmMYB111 Manipulates the Leaf Senescence of Welwitschia by Integrative Regulation of Abscisic Acid Biosynthesis, Chlorophyll Degradation and Nitrogen Transportation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Welwitschia mirabilis has been well noted for its two continuously grown leaves which could survive for thousands of years in the desert. Compared to great efforts on elucidation of Welwitschia's leaf adaptivity to external stresses, the regulatory mechanism of its internal leaf aging was largely unknown.
Han Xu, Qingqing Song, Junnan Wan, Jiapeng Han, Qingfeng Wang, Tao Wan   +5 more
wiley   +1 more source

Long‐term sub‐erythemal UVB exposure does not impact circadian rhythms in mice under standard and rotating shift light conditions

Photochemistry and Photobiology, EarlyView.
Circadian disruption is a potential carcinogen, but the impact of environmental carcinogens on circadian rhythms is unclear. Here we evaluated the impact of chronic UVB exposure with environmental‐ and genetic‐induced circadian disruption on mouse rhythmic locomotor activity and clock gene expression. Created in BioRender. Cone, S.
Adam J. Greer, Sean J. Cone, Rachel Bernstein, Elizabeth Schuetz, Narayani Prasad Kar, Bala S. C. Koritala, Shobhan Gaddameedhi   +6 more
wiley   +1 more source

Factors determining chromosomal localization of transposable elements in plants

Plant Biology, EarlyView.
We review transposon chromosomal niches, and the functional consequences of their specific chromosomal localization in plants. Abstract Transposable elements (TEs) constitute a significant part of plant genomes and shape their genomic landscape. While some TEs are ubiquitously dispersed, other elements specifically occupy discrete genomic loci.
E. Kejnovsky, P. Jedlicka, M. Lexa, Z. Kubat   +3 more
wiley   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source