Results 321 to 330 of about 515,505 (407)

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, Volume 15, Issue 6, Page 949-962, June 2025.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

Dual‐Functional Hafnium Oxide Nanoplatform Combining High‐Z Radiosensitization With Bcl‐2 Gene Silencing for Enhanced Cancer Radiotherapy

Advanced Healthcare Materials, Volume 14, Issue 15, 10 June, 2025.
A dual‐functional hafnium oxide nanoplatform is developed for enhanced cancer radiotherapy. This innovative system combines the inherent radiosensitizing properties of high‐Z hafnium oxide with Bcl‐2 gene‐silencing capabilities. The nanoplatform demonstrated synergistic enhancement of radiotherapy efficacy through increased generation of reactive ...
Seungyong Shin, Ga‐Hyun Bae, Jun‐Hyeok Han, Ha Eun Shin, Joo Dong Park, Seunghyo Ko, Eun‐Young Koh, Jieun Han, Su Chul Han, Jason Joon Bock Lee, Dong‐Hyun Kim, Heerim Nam, Wooram Park   +12 more
wiley   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinhui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

The Future of Pathogen Detection in Aquaculture: Miniature Labs, Field‐Compatible Assays, environmental DNA and RNA, CRISPR and Metatranscriptomics

Aquaculture, Fish and Fisheries, Volume 5, Issue 3, June 2025.
ABSTRACT Inland recirculating aquaculture is a thriving food industry providing sustainable and locally sourced high‐quality protein. However, its expansion is accompanied by emerging challenges regarding the spread of pathogens and diseases. Detection and management of pathogens in aquaculture remain underdeveloped compared to other animal farming ...
Jessica Rieder, Anastasiia Berezenko, Alexandra Meziti, Irene Adrian‐Kalchhauser   +3 more
wiley   +1 more source

Topical Mupirocin Treatment Reduces Interferon and Myeloid Signatures in Cutaneous Lupus Erythematous Lesions Through Targeting of Staphylococcus Species

Arthritis &Rheumatology, Volume 77, Issue 6, Page 705-715, June 2025.
Objective Cutaneous lupus erythematosus (CLE) is an inflammatory skin manifestation of systemic lupus erythematosus. Type I interferons (IFNs) promote inflammatory responses and are elevated in CLE lesions. We recently reported that CLE lesions are frequently colonized with Staphylococcus aureus.
Lisa Abernathy‐Close, Joseph Mears, Allison C. Billi, Sirisha Sirobhushanam, Celine Berthier, Annie Lu, Zeran Zhang, Amy Hurst, Johann E. Gudjonsson, J. Michelle Kahlenberg   +9 more
wiley   +1 more source

Clinical Significance of Observation of Micrometastasis in Regional Lymph Nodes Using Reverse Transcriptase-Polymerase Chain Reaction for Carcinoembryonic Antigen and Cytokeratin 20 against Cumulative Disease-Free Survival in Colorectal Cancer

, 2003
MOTOKAZU SATO, Kazuya Yamaguti, Manabu Futamura, Takao Takahashi, Shigetoyo Saji   +4 more
openalex   +2 more sources

SPARC Promotes Aerobic Glycolysis and 5‐Fluorouracil Resistance in Colorectal Cancer Through the STAT3/HK2 Axis

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background Chemotherapy has been used extensively in the clinic to treat colorectal cancer (CRC). Nevertheless, cancer cells usually develop chemoresistance under chemotherapy stress, leading to treatment failure. At present, the mechanism of chemoresistance in patients with CRC is not fully understood. Methods Firstly, Secreted protein acidic
Jingrong Xiang, Huan Zhang, Kanger Shen, Jie Feng, Kexi Yang, Tongguo Shi, Qinhua Xi   +6 more
wiley   +1 more source

Gut microbiota‐derived trimethylamine‐N‐oxide inhibits SIRT1 to regulate SM22α‐mediated smooth muscle cell inflammation and promote atherosclerosis progression

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Gut microbiota‐derived metabolite TMAO aggravates atherosclerosis by inhibiting SIRT1, leading to the downregulation of SM22α and promoting smooth muscle cell inflammation via the NF‐κB pathway. This study integrates multi‐omics and in vivo validation to uncover novel therapeutic targets in TMAO–SIRT1–SM22α signaling, offering new insights into ...
Yajuan Yin, Mei Wei, Xiufang Jiang, Mei Liu, Xiaocui Shi, Xiao Zhang, Le Wang, Gang Liu, Mingqi Zheng, Fangfang Ma   +9 more
wiley   +1 more source