Results 71 to 80 of about 558,507 (269)
Recent advancements in smart responsive tissue adhesives for medical applications
Frontiers in MedicineBioadhesives have emerged as a promising alternative to conventional sutures, offering rapid and robust tissue integration while overcoming limitations such as time-consuming procedures and risks of secondary tissue damage.
Shiqi Lin +5 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Zagazig Journal of Pharmaceutical Sciences, 2013 Stroke is a leading cause of death and permanent disability in adults worldwide. The only FDA-approved treatment for acute ischemic stroke is the intravenous recombinant tissue plasminogen activator (rt-PA) within 3 hours of onset Among the mechanisms ...
Waleed Barakat +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Drug-tolerant persister cells: the deadly survivors in hematological malignancies
Frontiers in PharmacologyAlthough the prognosis of patients with hematologic cancers has improved significantly owing to the advance of radiotherapy, chemotherapy, targeted therapies, immunotherapies, and hematopoietic stem cell transplantation therapy, disease relapse and ...
Qianying Ma +8 more
doaj +1 more source
Bisimulations and Reversibility
Concurrency and causality can be expressed within a labelled transition system by exploiting reversibility of transitions. It is natural to ask what behavioural equivalences can be captured by bisimulations in the reversible setting. In this paper we work with keyed configuration structures and CCS K, establish an operational correspondence between the
Clément Aubert +2 more
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reversible hypopigmentation with pazopanib
Indian Journal of Medical and Paediatric Oncology, 2018 Tablet Pazopanib known to cause Hypo pigmentation and Hyperpigmentation as per various literature reports. We report here a case of reversible hypopigmentation with Pazopanib in a patient treated for spindle cell sarcoma.
B J Srinivasa +3 more
doaj +1 more source
Reversed Bodies, Reversed Brains, and (Some) Reversed Behaviors: Of Zebrafish and Men [PDF]
Developmental Cell, 2005 Although zebrafish with situs inversus show complete reversal of normal visceral and cerebral asymmetries, they show left-right reversal of only some behaviors, with others continuing to show species-typical lateralization. The implication is that, as in humans, there are at least two independent mechanisms for generating asymmetry.
openaire +2 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source