Results 61 to 70 of about 58,244 (329)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Novel Reversible Comparator Design in Quantum Dot-Cellular Automata with Power Dissipation Analysis

Applied Sciences, 2022
In very large-scale integration (VLSI) circuits, a partial of energy lost leads to information loss in irreversible computing because, in conventional combinatorial circuits, each bit of information generates heat and power consumption, thus resulting in
Mohsen Vahabi, Pavel Lyakhov, Ali Newaz Bahar, Akira Otsuki, Khan A. Wahid   +4 more
doaj   +1 more source

Trace Complexity of Chaotic Reversible Cellular Automata

, 2014
Delvenne, K\r{u}rka and Blondel have defined new notions of computational complexity for arbitrary symbolic systems, and shown examples of effective systems that are computationally universal in this sense.
A.R. Smith III, B. Durand, C.H. Bennett, H.B. Axelsen, J.-C. Delvenne, J.-C. Delvenne, M. Boyle, M. Cook, M. Nasu, P. Kůrka, R.L. Devaney, W. Thomas   +11 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

RSCV: Reversible Select, cross and variation architecture in quantum‐dot cellular automata

IET Quantum Communication, 2022
In the past few years, CMOS semiconductor has been a growing and evolving technology in VLSI. However, due to the scaling issue and some other constraints like heat generation, high power consumption QCA (quantum cellular automata) emerged as an ...
Arpita Kundu, Jadav Chandra Das, Debashis De   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Energy dissipation dataset for reversible logic gates in quantum dot-cellular automata

Data in Brief, 2017
This paper presents an energy dissipation dataset of different reversible logic gates in quantum-dot cellular automata. The proposed circuits have been designed and verified using QCADesigner simulator. Besides, the energy dissipation has been calculated
Ali Newaz Bahar, Mohammad Maksudur Rahman, Nur Mohammad Nahid, Md. Kamrul Hassan   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Reversible Computing: Review of the Problem and New Results (Fault Tolerance and Cryptography)

Современные информационные технологии и IT-образование, 2019
The paper considers the main provisions of reversibility as a new paradigm for the development of computer technology. The first sections are of an overview nature.
Sergey Gurov, Aleksey Zhukov, Dmitry Zakablukov, Georgy Kormakov   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source