Results 101 to 110 of about 604,680 (287)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network Communication with operators in Dedekind Finite and Stably Finite Rings [PDF]

open access: yes, 2016
Messages in communication networks often are considered as "discrete" taking values in some finite alphabet (e.g. a finite field). However, if we want to consider for example communication based on analogue signals, we will have to consider messages that
Riis, S
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Electronically tunable luminescent bis(biaryl-substituted triarylamine) ((bTAA)2) electrophores prepared via oxidative dimerization of modularly accessible arylated monomers [PDF]

open access: yesRSC Advances
Bis(biaryl-substituted triarylamines) ((bTAA)2) are readily synthesized by oxidative homocoupling from modularly accessible biaryl-substituted triarylamine (bTAA) monomers.
Regina Kohlbecher   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Results on Reversible Properties in Skew Monoid Rings

open access: yes
This paper introduces the concept of \(\sigma\)-skew strongly \(M\)-nil-reversible rings as a unified generalization of strongly \(M\)-reversible and \(M\)-compatible rings.
Eltiyeb Ali, Awn Alqahtani
core   +1 more source

FIXED PROLONGED REGIME OF COMBINED ORAL CONTRACEPTIVES (COC) INTAKE IN SOLUTION OF CLASSIC CONTRACEPTION ISSUES (LITERATURE REVIEW)

open access: yesМедицинский совет, 2017
Combined oral contraceptives (COC) – the most popular reversible method to prevent unwanted pregnancy used in the whole world. The popularity of COC remains unchanged since the moment of their appearance [1]. Thus, in the US COC are used by each 4 out of
V. N. Prilepskaya, E. A. Minaeva
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Intra-Stromal Corneal Ring Segments

open access: yesDelhi Journal of Ophthalmology, 2013
Intra-stromal corneal ring segments (ICRs) are a new modality in the treatment of corneal ectactic disorders like keratoconus, post lasik ectasia and pellucid marginal degeneration.
Ramendra Bakshi   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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