Results 121 to 130 of about 365,073 (343)

Accidental child driveway runovers: Exploring Waikato data and the efficacy of existing responses [PDF]

, 2009
While the numbers of accidents are not high, there is little doubt that driveway runovers are an ongoing, often fatal and inevitably avoidable tragedy for children and their families. In many cases the driver is an immediate family member, or a neighbour
Campbell, Maxine M., Hunter, John, Poulgrain, Hayley Mills   +2 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Reversing the Interfacial Electric Field in Metal Phosphide Heterojunction by Fe‐Doping for Large‐Current Oxygen Evolution Reaction

Advanced Science
Developing non‐precious‐metal electrocatalysts that can operate with a low overpotential at a high current density for industrial application is challenging. Heterogeneous bimetallic phosphides have attracted much interest.
Zhong Li, Chengshuang Xu, Zheye Zhang, Shan Xia, Dongsheng Li, Liren Liu, Peng Chen, Xiaochen Dong   +7 more
doaj   +1 more source

Memory-induced current reversal of Brownian motors

Physical Review E
Kinetics of biological motors such as kinesin or dynein is notably influenced by viscoelastic intracellular environment. The characteristic relaxation time of the cytosol is not separable from the colloidal timescale and therefore their dynamics is inherently non-Markovian.
Mateusz Wiśniewski, Jakub Spiechowicz
openaire   +3 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Diagnostic difficulties in progressive multifocal leukoencephalopathy: a case report

Folia Neuropathologica
Progressive multifocal leukoencephalopathy (PML) is a demyelination disease of the central nervous system (CNS) caused by viral infection with John Cunningham polyomavirus (JC virus, JCV). PML affects mainly patients with immunodeficiency.
Angelika Stapińska-Syniec, Michał Sobstyl, Katarzyna Kurowska, Albert Acewicz, Teresa Wierzba-Bobrowicz   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Current Reversals in Chaotic Ratchets

, 2001
The problem of the classical deterministic dynamics of a particle in a periodic asymmetric potential of the ratchet type is addressed. When the inertial term is taken into account, the dynamics can be chaotic and modify the transport properties. By a comparison between the bifurcation diagram and the current, we identify the origin of the current ...
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source