Results 101 to 110 of about 94,375 (298)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Reversing the sign of current-current correlations
, 2002 Current-correlations are a very sensitive probe of the fluctuations of small conductors. For non-interacting particles injected from thermal sources there is a simple connection between the sign of correlations and statistics: current-current ...
Buttiker, Markus
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
III.—On the reversal of the respiratory current in the Decapods [PDF]
Annals and Magazine of Natural History, 1898 n ...
openaire +2 more sources
Advanced ScienceDeveloping non‐precious‐metal electrocatalysts that can operate with a low overpotential at a high current density for industrial application is challenging. Heterogeneous bimetallic phosphides have attracted much interest.
Zhong Li +7 more
doaj +1 more source
Research advances of nano-delivery system for diagnosing and treating renal fibrosis
Linchuang shenzangbing zazhiRenal fibrosis is a common pathological manifestation of chronic kidney disease （CKD）. Since the process of renal drug delivery is rather complex, there is currently no effective remedy for reversing renal fibrosis （RF）.
Chen Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Wind-Forced Reversing Jets in the Western Equatorial Pacific
, 2000 Upper-ocean zonal currents in the western equatorial Pacific are remarkably variable, changing direction both with time and depth. As a part of the Tropical Ocean and Global Atmosphere Coupled Ocean-Atmosphere Response Experiment, an enhanced monitoring ...
Cronin, Megan F. +2 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source