Results 81 to 90 of about 94,375 (298)
Loss of β-cell identity and dedifferentiation, not an irreversible process?
Frontiers in EndocrinologyType 2 diabetes (T2D) is a polygenic metabolic disorder characterized by insulin resistance in peripheral tissues and impaired insulin secretion by the pancreas. While the decline in insulin production and secretion was previously attributed to apoptosis
Sumit Patel +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders
Frontiers in Pharmacology, 2018 Adenosine A2A receptor (A2AR) antagonists have emerged as complementary non-dopaminergic drugs to alleviate Parkinson’s disease (PD) symptomatology.
Fabiana Núñez +12 more
doaj +1 more source
The Depositional Record, 2020 The upper Cambrian Wilberns Formation in central Texas records deposition on a low‐gradient shelf within a mixed carbonate–siliciclastic tidal‐flat system that changes offshore to subtidal shelf and open‐marine oolitic skeletal shoals with large ...
Daniel J. Lehrmann +14 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Sustainable energy in Brazil: Reversing past achievements or realizing future potential
, 2014 Sustainable energy in Brazil: Reversing past achievements or realizing future potential / Mari Luomi. Oxford Institute for Energy Studies, Aug. 2014, 55 p.
Danièle Revel
core +1 more source
Journal of VirologyThe persistence of latent HIV-1 reservoirs remains a critical barrier to cure. Current “shock and kill” strategies are limited by ineffective latency-reversing agents (LRAs) and poor understanding of epigenetic regulation.
Tao Yang +16 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Deepfake Face Traceability with Disentangling Reversing Network
, 2022 Deepfake face not only violates the privacy of personal identity, but also confuses the public and causes huge social harm. The current deepfake detection only stays at the level of distinguishing true and false, and cannot trace the original genuine ...
Han, Zhen +3 more
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