Results 91 to 100 of about 94,375 (298)
Impact of transcranial direct current stimulation (tDCS) on neuronal functions
Frontiers in Neuroscience, 2016 Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, modulates neuronal excitability by the application of a small electrical current.
Suman Das +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Research of RLC-chain of sinusoidal voltage with controlled inductive element reversing
, 2011 Upon reversing of inductive element the sin-voltage RLC-circuit processes due to controlled commutator were analyzed. Obtained recurrent formulae enable to determine the capacity voltage and the inductive current at any temporal intervals irrespective of
Шидловская, Н.А.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Reversing Language Shift in Galicia : A Present-Day Perspective
, 2010 The present thesis is about the current linguistic situation in the Spanish province of Galicia and about the prospects of the Galician language in modern times.
Skobel, Ekaterina
core
Research on Local Scour at Bridge Pier under Tidal Action
MATEC Web of Conferences, 2015 Through the local scour test at bridge pier under tidal action in a long time series, this paper observes the growing trend of the deepest point of local scour at bridge pier under tidal conditions with different characteristic parameters, analyzes the ...
Wang Jianping
doaj +1 more source
Cell Reports, 2014 Within neurons, Ca2+-dependent inactivation (CDI) of voltage-gated L-type Ca2+ channels shapes cytoplasmic Ca2+ signals. CDI is initiated by Ca2+ binding to channel-associated calmodulin and subsequent Ca2+/calmodulin activation of the Ca2+-dependent ...
Philip J. Dittmer +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Research Progress on Chinese Herbal Medicine Components Targeting Ferroptosis for Cancer Therapy
MoleculesRecent studies indicate that ferroptosis shows unique advantages in oncotherapy, particularly in reversing multidrug resistance (MDR). Despite current therapeutic advancements, the treatment of high-incidence malignancies with dismal prognoses continues ...
Nanhao Zhou +3 more
doaj +1 more source