Results 91 to 100 of about 365,073 (343)

50/50 by 2020: poverty and redistributive politics in post-independence Fiji [PDF]

open access: yes, 2015
The affirmative action program launched by the Fiji Government in 2002 espoused a '50/50 by 2020' vision; that is, by the year 2020, some 50 per cent of all economic activities would be owned by the indigenous population.
Chand, Satish
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Loss of β-cell identity and dedifferentiation, not an irreversible process?

open access: yesFrontiers in Endocrinology
Type 2 diabetes (T2D) is a polygenic metabolic disorder characterized by insulin resistance in peripheral tissues and impaired insulin secretion by the pancreas. While the decline in insulin production and secretion was previously attributed to apoptosis
Sumit Patel   +3 more
doaj   +1 more source

PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders

open access: yesFrontiers in Pharmacology, 2018
Adenosine A2A receptor (A2AR) antagonists have emerged as complementary non-dopaminergic drugs to alleviate Parkinson’s disease (PD) symptomatology.
Fabiana Núñez   +12 more
doaj   +1 more source

Controls on microbial and oolitic carbonate sedimentation and stratigraphic cyclicity within a mixed carbonate‐siliciclastic system: Upper Cambrian Wilberns Formation, Llano Uplift, Mason County, Texas, USA

open access: yesThe Depositional Record, 2020
The upper Cambrian Wilberns Formation in central Texas records deposition on a low‐gradient shelf within a mixed carbonate–siliciclastic tidal‐flat system that changes offshore to subtidal shelf and open‐marine oolitic skeletal shoals with large ...
Daniel J. Lehrmann   +14 more
doaj   +1 more source

Spin supercurrent and phase-tunable triplet Cooper pairs via magnetic insulators

open access: yes, 2015
We demonstrate theoretically that a dissipationless spin current can flow a long distance through a diffusive normal metal by using superconductors interfaced with magnetic insulators.
Gomperud, Ingvild, Linder, Jacob
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Impact of transcranial direct current stimulation (tDCS) on neuronal functions

open access: yesFrontiers in Neuroscience, 2016
Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, modulates neuronal excitability by the application of a small electrical current.
Suman Das   +7 more
doaj   +1 more source

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