Results 191 to 200 of about 213,560 (338)

Momentum and Reversion

, 2015
Mukul Pal
openalex   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Analysis of a household-scale model for the invasion of Wolbachia into a resident mosquito population. [PDF]

J Math Biol
Barlow A, Penington S, Adams B.
europepmc   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Single-cell analysis of heterogeneity in reverted hiPSC-derived human hepatic stellate cells. [PDF]

JHEP Rep
Wang X, Ha EH, Bian L, Feng Z, Zhang F, O'Shaughnessy K, Wang L, Hochwald A, Zheng Y, Chen W, Zhang Y, Wu X.   +11 more
europepmc   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

<i>Coxiella burnetii</i> Nine Mile II Δ<i>cbu0533</i> as a suitable laboratory replacement strain. [PDF]

Microbiol Spectr
Pierce KN, Frederick CS, Farquhar C, Voth DE, Long CM.   +4 more
europepmc   +1 more source

Reversion of Aberrant Plants Transformed with Agrobacterium rhizogenes Is Associated with the Transcriptional Inactivation of the T_L-DNA Genes [PDF]

, 1988
Vilas P. Sinkar, Frank F. White, Ian J. Furner, Mitchell S. Abrahamsen, Francois Pythoud, Milton P. Gordon   +5 more
openalex   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Evaluation of the vaccine candidate ASFV-MEC-01: safety, efficacy, transmission dynamics, and assessment of reversion to virulence. [PDF]

Emerg Microbes Infect
Tran LH, Bui AN, Kwon HI, Dao TD, Weerawardhana A, Tran TM, Vu HT, Nguyen QD, Gamage N, Kim MH, Moon JY, Hong JH, Kim J, Kim Y, Kim Y, Kim W, Kim G, Lee SI, Kim YS, Lee HS, Lee JY, Yoon IJ, Mo IP, Jheong W, Yoo SS, Bui VN, Lee JS.   +26 more
europepmc   +1 more source