Results 51 to 60 of about 2,301,879 (290)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Not “big is bad” but “closed is bad”? Exploring dynamic competition in generative AI

Market and Competition Law Review
Scholars have seized upon studies on economic concentration to revive the idea that “big is bad”. A recent addition to the literature, by James Bessen, shares a concern for declining disruption rates but argues instead that “closed is bad”.
Friso Bostoen, Lola Montero Santos, Anouk van der Veer   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

From pillow to podium: a review on understanding sleep for elite athletes

Nature and Science of Sleep, 2018
Shannon O’Donnell, Christopher M Beaven, Matthew W Driller Health, Sport and Human Performance, University of Waikato, Hamilton, New Zealand Abstract: Sleep is considered vital to human health and well-being, and is critical to physiological and ...
O'Donnell S, Beaven CM, Driller MW
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Competition and cooperation:aspects of dynamics in sandpiles

, 2005
In this article, we review some of our approaches to granular dynamics, now well known to consist of both fast and slow relaxational processes. In the first case, grains typically compete with each other, while in the second, they cooperate.
Anita Mehta, Bagnold R A, Berg J, Bernal J D, Bollobas B, Brown R L, Caballero G, Coniglio A, Doi M, Edwards S F, Edwards S F, Edwards S F, Fukushima E, G C Barker, J M Berg, J M Luck, Kurchan J, Liu C H, Luck J M, Luck J M, Luck J M, Luck J M Mehta A, Marinari E, Mehta A, Mehta A, Mehta A, Mehta A, Mehta A, Mehta A, Mézard M, Reynolds O, Smoluchowski M V   +31 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

[Review of] Susan Olzak. The Dynamics of Ethnic Competition and Conflict [PDF]

, 1994
Susan Olzak’s work, The Dynamics of Ethnic Competition and Conflict, is informative and contributes to an understanding of ethnic violence from an historical perspective.
Hood, David L.
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

The strategic use of patents and its implications for enterprise and competition policies [PDF]

, 2007
This report was commissioned as a study into the strategic use of patents. In the course of its case investigations and legislative reviews the European Commission became aware of changes in the use of intellectual property, in particular the use of ...
Hall, Bronwyn, Harhoff, Dietmar, Hoisl, Karin, von Graevenitz, Georg, Wagner, Stefan   +4 more
core