Results 111 to 120 of about 65,536,373 (247)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Systematic quantitative literature review: Reviewing interdisciplinary literature on host-children

, 2019
The United Nations Sustainable Development Goals (UNSDG) aims to protect and eliminate all forms of child labour by 2025 (United Nations, 2018). According to the International Labour Organization (2002), roughly 19 million workers in tourism-related ...
Khoo-Lattimore, Catheryn, Yang, Chiao Ling, Yang, Mona Ji Hyun   +2 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

University Rankings Literature Review [Dataset]

[EN] This dataset includes bibliographic metadata on publications related to university rankings, used as a baseline for a literature review on the topic.
Orduña-Malea, Enrique
core   +1 more source

Aboriginal and Torres Strait Islander art economies project: literature review [PDF]

, 2013
Executive summary: This literature review surveys writing about the Aboriginal and Torres Strait Islander art and craft sector of remote Australia. The review has been compiled as a foundational text for the ‘Aboriginal and Torres Strait Islander Art ...
Lisa Stefanoff, Woodhead, A., Tim Acker, Acker, Tim, Stefanoff, L., Alice Woodhead   +5 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Topic familiarity and extraversion in ESL oral assessment: a conceptual review [PDF]

Oral performance among test-takers in proficiency English tests has shown to be prone to variability due to its rater-mediated nature. Test-takers could better lead their assessment preparation if they understood more about how to optimise their ...
Noordin, Nooreen, Ahmad Bukhari, Nurul Iman, Razali, Abu Bakar, Ismail, Lilliati, Abu Kassim, Noor Lide   +4 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Enteral Stomas: Impact on the Child and the Family Impacto del estoma enteral en el niño y la familia Impacto do estoma enteral na criança e sua família

Avances en Enfermería, 2010
<span style="font-family: verdana; font-size: x-small;"><p>The consequences at the family level of having a child with enteric stoma have been a matter of deep concern in the nursing practice. This type of stoma is performed in children as an
ANGELO MARGARETH, GUERRERO SANDRA
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