Results 161 to 170 of about 2,417,430 (400)
Use of topical imiquimod in the treatment of VIN: a case report and review of the literature
International Journal of Women's Dermatology, 2016 Vulvar intraepithelial neoplasia (VIN) is a premalignant disease of the vulvar squamous epithelium. Standard treatment for VIN lesions is surgical excision. Alternative therapeutic options for conservative treatment have been sought by patients to prevent disfigurement and to preserve sexual function. We present such a patient in whom topical imiquimod
Chelsea Grimes +3 more
openaire +4 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
THE ADVANCES IN USE OF TOPICAL ANESTHESIA; A REVIEW OF RECENT LITERATURE
, 2018 Introduction: Administrating local anesthetics with injections is associated with much pain and is known to lead to the development of edema of tissues that can negatively affect the surgical wound. The use of topical anesthetics has been increasing in several procedures due to its improved efficacy and decreased pain when compared to injected local ...
openaire +2 more sources
Ensure a Healthy Start: Prevent and Reduce Childhood Exposure to Harmful Chemicals [PDF]
, 2015 This brief provides an explanation of key concepts and considerations funders will encounter when exploring philanthropic opportunities in a new topic area, and strategies and resources funders can leverage to achieve high impact.It also presents an ...
core
Varicocele and Testicular Pain: A Review
The World Journal of Men's Health, 2019 Varicocele is the dilatation of the scrotal portion of pampiniform plexus and the internal spermatic venous system. About 15% of men suffer from scrotal varicocele and 2% to 10% of them complain of pain.
Sunghyun Paick, Woo Suk Choi
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
A framework for the classification of accounts manipulations [PDF]
Accounts manipulations have been a matter of research, discussion and, even, controversy in several countries such as the United States, Canada, the United Kingdom, Australia and France. The objective of this paper is to elaborate a general framework for
BRETON, Gaetan, STOLOWY, Herve
core
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
PTSD in Military Veterans: History, Evolution, and Policy Implications [PDF]
, 2012 It is estimated that 30% of men and women who have served in war zones will develop post-traumatic stress disorder (PTSD). Yet, it is still a topic that is not fully understood or supported by American civilian culture.
Albain, Christine
core +1 more source