Results 111 to 120 of about 37,065,244 (274)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Kilifi County Budget Review and Outlook Paper 2018

, 2018
This 2018 County Budget Review and Outlook Paper (CBROP) is a key document that links policy, planning and budgeting. The County’s policies are spelled in, among other documents, the 2018 County Fiscal Strategy Paper (CFSP) and undergirds this 2018 CBROP.

core   +1 more source

Review Paper on Penetrating Brain Injury: Ethical Quandaries in the Trauma Bay and Beyond. [PDF]

Ann Surg, 2023
Zakrison TL, Essig R, Polcari A, McKinley W, Arnold D, Beyene R, Wilson K, Rogers S, Matthews JB, Millis JM, Angelos P, O'Connor M, Mansour A, Goldenberg F, Spiegel T, Horowitz P, Das P, Slidell M, Chokshi N, Okeke I, Barth R, Wilkins HE, Kass-Hout T, Lazaridis C.   +23 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

The science behind soft skills: Do's and Don'ts for early career researchers and beyond. A review paper from the EU-CardioRNA COST Action CA17129. [PDF]

Open Res Eur, 2023
Acharya S, Preda MB, Papatheodorou I, Palioura D, Giardoglou P, Tsata V, Erceg S, Barbalata T, Ben-Aicha S, Martino F, Nicastro L, Lazou A, Beis D, Martelli F, Sopic M, Emanueli C, Kardassis D, Devaux Y, EU-CardioRNA COST Action CA17129..   +18 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Genetic Diversity of Microcystin Producers (Cyanobacteria) and Microcystin Congeners in Aquatic Resources across Africa: A Review Paper. [PDF]

Toxics, 2022
Chia MA, Ameh I, George KC, Balogun EO, Akinyemi SA, Lorenzi AS.   +5 more
europepmc   +1 more source

National Opera Review discussion paper [PDF]

, 2015
On 25 September 2015, the National Opera Review Discussion Paper was released by the National Opera Review Panel.  The Discussion Paper considers the financial viability, artistic vibrancy and audience access of Australia’s four major opera ...
Helen Nugent
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source