Results 231 to 240 of about 2,023,324 (272)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Initiatives to support nursing workforce sustainability: A rapid umbrella review. [PDF]

Int J Nurs Stud Adv
Tomblin Murphy G, Sampalli T, Elliott Rose A, Martin-Misener R, Sim M, Indar A, Murdoch J, Hancock K, Salmaniw S, Murphy-Boyle K, Benson K, MacKenzie A, Chamberland-Rowe C.   +12 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Concerns of Using Large Language Models in Health Care Research and Practice: Umbrella Review. [PDF]

J Med Internet Res
Yarar F, Addis P, Fairweather M, Craig D, O'Keefe H.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluating the Methodological Quality of Artificial Intelligence-Assisted Systematic Reviews: Protocol for a Mixed Methods Meta-Research Study. [PDF]

JMIR Res Protoc
Jay M, Morgan M, Straus SE, Wilson E, Sutradhar R, Yu C, Gotlib Conn L, Dharma C, Lipscombe L, Eskander A.   +9 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Beyond Model Development in Healthcare AI: Post-Development Robustness, Post-Deployment Monitoring, and Lifecycle Governance-A Scoping Review of Reviews. [PDF]

Healthcare (Basel)
El Arab RA, Mustafa MH, Almagharbeh WT, Saleem NH, Al Abdulmohsen S, Boathab R, Bu Washl M.   +6 more
europepmc   +1 more source

Book Reviews

, 1966
Reviews and Notes, Book Reviews
core  

Mapping the evidence on stillbirth prevention across the reproductive continuum: an umbrella review. [PDF]

BMJ Open
Gadapani Pathak B, Vats P, Manna S, Yadav S, Bhatt A, Mukherjee R, Patil R, Dayma G, Mazumder S.   +8 more
europepmc   +1 more source