Results 261 to 270 of about 8,814,223 (344)
Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher +11 morewiley +1 more sourceProtocol for an umbrella review of systematic reviews evaluating the efficacy of digital health solutions in supporting adult cancer survivorship care. [PDF]
PLoS OneKeane D, Calbimonte JP, Pawłowska E, Kassianos AP, Medina JC, Gregório J, Serra-Blasco M, Celebic A, Di Meglio A, Asadi-Azarbaijani B, Foster C, Donohoe CL, Mafra A, Backes C, Ochoa-Arnedo C, Gezer D, Bozkul G, Horata ET, Özkan E, Prue G, İşcan G, Dural G, Bahçecioğlu G, Ersöğütçü F, Bērziņa G, Bektas H, Vaz-Luis I, Mlakar I, Rocha-Gomes J, O'Connor M, Clara MI, Karekla M, Hagen MH, İmançer MS, Çöme O, Mevsim V, Aksoy N, Martins RM, Yokuş SE, Bayram SB, Can AA, Brandão T, Saab MM, Muluk NB, Yıldırım Z, Podina IR, Karadağ S, Erden S, Semerci R, Aydin A, Frountzas M, Cura ŞÜ, Ruveyde A, Billis A, Calleja-Agius J, Vojvodic K, Jaswal P, Sahin E, Ilgaz A, Pilleron S, Hegarty J. +60 moreeuropepmc +1 more sourceShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones +11 morewiley +1 more sourceTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker +19 morewiley +1 more source