Results 301 to 310 of about 8,814,223 (344)

Peer reviews of peer reviews: A randomized controlled trial and other experiments. [PDF]

PLoS One
Goldberg A, Stelmakh I, Cho K, Oh A, Agarwal A, Belgrave D, Shah NB.   +6 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Vaccine Research Trends in Africa from 2016 to Mid-2024: A Bibliometric Analysis. [PDF]

Vaccines (Basel)
Iwu-Jaja C, Ndwandwe D, Malinga T, Mathebula L, Mazingisa A, Wiysonge CS.   +5 more
europepmc   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Involving adolescents in evidence syntheses: an umbrella review. [PDF]

Syst Rev
Warraitch A, Sulowska M, Wacker C, Lee M, Bruce D, Hernon J, Khraisha Q, Hadfield K.   +7 more
europepmc   +1 more source

Medical education research quality (MERSQ) checklist development: Are searches of BEME and non-BEME reviews standard?: A mixed method study. [PDF]

Medicine (Baltimore)
Alizadeh M, Rahmati R, Zarimeidani F, Hasani F, Ghaedi A, Bazrgar A, Hosseini Doalame R, Vahedi H, Hekmat H, Omidi N.   +9 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Global prevalence and contributing factors of nurse burnout: an umbrella review of systematic review and meta-analysis. [PDF]

BMC Nurs
Getie A, Ayenew T, Amlak BT, Gedfew M, Edmealem A, Kebede WM.   +5 more
europepmc   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews

Lee J, Barnett P, Yang J, Appleton R, Lloyd-Evans B, Hahn J, Rich N, Francis E, Mitchell L, Driskell E, Unkelbach A, Johnson S.   +11 more
europepmc   +1 more source