Results 61 to 70 of about 8,814,223 (344)

Systematic review and cost-effectiveness evaluation of ‘pill-in-the-pocket’ strategy for paroxysmal atrial fibrillation compared to episodic in-hospital treatment or continuous antiarrhythmic drug therapy

open access: yesHealth Technology Assessment, 2010
Background: Atrial fibrillation (AF) is a tachyarrhythmia characterised by unco-ordinated atrial activation with consequent deterioration of impairment of atrial function and a rapid, irregular heartbeat.
C Martin Saborido   +5 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

PeRView: A Framework for Personalized Review Selection Using Micro-Reviews [PDF]

open access: yesarXiv, 2018
In the contemporary era, social media has its influence on people in making decisions. The proliferation of online reviews with diversified and verbose content often causes problems inaccurate decision making. Since online reviews have an impact on people of all walks of life while taking decisions, choosing appropriate reviews based on the ...
arxiv  

Review Helpfulness Scores vs. Review Unhelpfulness Scores: Two Sides of the Same Coin or Different Coins? [PDF]

open access: yesIEEE Transactions on Engineering Management, vol. 71, pp. 8031-8044, 2024
Evaluating the helpfulness of online reviews supports consumers who must sift through large volumes of online reviews. Online review platforms have increasingly adopted review evaluating systems, which let users evaluate whether reviews are helpful or not; in turn, these evaluations assist review readers and encourage review contributors.
arxiv   +1 more source

The clinical effectiveness and cost-effectiveness of the PROGENSA® prostate cancer antigen 3 assay and the Prostate Health Index in the diagnosis of prostate cancer: a systematic review and economic evaluation

open access: yesHealth Technology Assessment, 2015
Background: There is no single definitive test to identify prostate cancer in men. Biopsies are commonly used to obtain samples of prostate tissue for histopathological examination.
Amanda Nicholson   +7 more
doaj   +1 more source

Workplace-based interventions to promote healthy lifestyles in the NHS workforce: a rapid scoping and evidence map

open access: yesHealth Services and Delivery Research, 2020
Background: The health and well-being of staff working in the NHS is a significant issue for UK health care. We sought to identify research relevant to the promotion of healthy lifestyles among NHS staff on behalf of NHS England.
Gary Raine   +4 more
doaj   +1 more source

Patient characteristics as effect modifiers for psoriasis biologic treatment response: an assessment using network meta-analysis subgroups

open access: yesSystematic Reviews, 2020
Background Network meta-analyses (NMAs) of psoriasis treatments, undertaken as part of the NICE Single Technology Appraisal (STA) process, have included heterogeneous studies.
Ros Wade, Sahar Sharif-Hurst, Sofia Dias
doaj   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

The quality of COVID-19 systematic reviews during the coronavirus 2019 pandemic: an exploratory comparison

open access: yesSystematic Reviews
Background The unprecedented volume and speed at which COVID-19-related systematic reviews (SRs) may have been produced has raised questions regarding the quality of this evidence.
Kevin T. McDermott   +5 more
doaj   +1 more source

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