Results 81 to 90 of about 70,053 (260)

A randomised, feasibility trial of a tele-health intervention for Acute Coronary Syndrome patients with depression (‘MoodCare’): study protocol. [PDF]

, 2011
Background Coronary heart disease (CHD) and depression are leading causes of disease burden globally and the two often co-exist. Depression is common after Myocardial Infarction (MI) and it has been estimated that 15-35% of patients experience depressive
Anna L Hawkes, Kathy Eadie, Hawkes, AL, Brian Oldenburg, Eadie, Kathy, Hollingsworth Bruce, Adrienne O'Neil, O'Neil, Adrienne, Bianca Chan, Taylor, C, Hawkes, Anna, Bruce Hollingsworth, Eadie, K, Chan Bianca, Michael Jelinek, John Atherton, Hawkes, A, Chan, Bianca, Atherton John, Sanderson, Kristy, O Neill, A, Hare, DL, Hare David L, David L Hare, O'Neil Adrienne, Eadie Kathy, Forbes, Andrew, Hollingsworth, B, Jelinek, M, Atherton, J, Atherton, John, Oldenburg, Brian, Hare, David L., Taylor C Barr, Taylor, CB, Jelinek, Michael, Hawkes Anna L, Kristy Sanderson, Hare, David, Hollingsworth, Bruce, Chan, B, Taylor, Craig, Forbes Andrew, Andrew Forbes, Sanderson, K, Oldenburg, B, Sanderson Kristy, Taylor, C. Barr, Oldenburg Brian, Taylor, Barr, C Barr Taylor, Forbes, A, Jelinek Michael, Hawkes, Anna L., O'Neil, A, Hare, D   +55 more
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

The Derivation and Validation of a Geriatric-Sensitive Perioperative Cardiac Risk Index (GSCRI) [PDF]

, 2016
Surgical patients age 65 and over face a high risk of cardiac complications. The Revised Cardiac Risk Index (RCRI) and the Gupta Myocardial Infarction or Cardiac Arrest (MICA) are widely used to predict perioperative cardiac risk but they are not ...
Alrezk, Rami
core  

Comparison of 4 Cardiac Risk Calculators in Predicting Postoperative Cardiac Complications After Noncardiac Operations

, 2018
© 2017 Elsevier Inc. The 2014 American College of Cardiology/American Heart Association Perioperative Guidelines suggest using the Revised Cardiac Risk Index, myocardial infarction or cardiac arrest, or American College of Surgeons—National Surgical ...
Steven L. Cohn, Cohn, Steven L, Cohn, S. L., Fernandez Ros, N., Fernandez Ros, Nerea, Nerea Fernandez Ros   +5 more
core   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Heart rate variability in the general population and its determining factors [PDF]

, 2008
Background: As the leading cause of mortality in Switzerland and many other developed countries, cardiovascular disease (CVD) is of high significance in public health: In 2003, CVD was the leading cause of death in Switzerland, accounting for 38% of ...
Felber Dietrich, Denise
core   +1 more source

The revised cardiac risk index is associated with morbidity and mortality independent of injury severity in elderly patients with rib fractures

, 2022
BACKGROUND: Risk factors for mortality and in-hospital morbidity among geriatric patients with traumatic rib fractures remain unclear. Such patients are often frail and demonstrate a high comorbidity burden.
Duffy, Caoimhe C, Forssten, Maximilian Peter, Mohseni, Shahin,, Bass, Gary Alan,, Cao, Yang,, Kaplan, Lewis J.,, Bass, Gary Alan, Cao, Yang, Sarani, Babak, Ismail, Ahmad Mohammad, Mohseni, Shahin, Duffy, Caoimhe C.,, Kaplan, Lewis J, Sarani, Babak,, Mohammad Ismail, Ahmad,, Forssten, Maximilian Peter,, Martin, Niels D, Martin, Niels D.,   +17 more
core   +1 more source

Perioperative Risk: Short Review of Current Approach in Non Cardiac Surgery

Journal of Cardiovascular Development and Disease
The rate of major surgery is constantly increasing worldwide, and approximately 85% are non-cardiac surgery. More than half of patients over 45 years presenting for non-cardiac surgical interventions have cardiovascular risk factors, and the most common:
Andreea Boghean, Cristian Guțu, Dorel Firescu   +2 more
doaj   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source