Results 101 to 110 of about 70,053 (260)

Association between preoperative geriatric nutritional risk index and major adverse cardiovascular and cerebrovascular events after non-cardiac surgery in older patients: a retrospective cohort study

BMC Geriatrics
Background Preoperative nutritional status impacts surgical outcomes. This study aimed to examine the association between preoperative Geriatric Nutritional Risk Index (GNRI) and the incidence of postoperative major adverse cardiovascular and ...
Zhisen Dai, Yanlin Wu, Huaqing Huang, Junheng Chen, Hui Jiang, Ying Wang, Huizhe Zheng   +6 more
doaj   +1 more source

Cardiac biomarkers as an important component of perioperative management of a patient with concomitant cardiac pathology

Медицина неотложных состояний
Background. Some patients who require elective noncardiac surgery are at increased risk of developing cardiovascular complications. Cardiac biomarkers are among the criteria recommended for patient assessment and prognosis.
M.O. Harbar, N.V. Matolinets, O.O. Yastremska, H.V. Svitlyk   +3 more
doaj   +1 more source

Determinants of Long‐Term Benefit From High Dose Melphalan With Autologous Stem Cell Transplant in AL Amyloidosis

American Journal of Hematology, EarlyView.
ABSTRACT High dose melphalan (HDM) with autologous stem cell transplant is an established treatment for systemic light chain amyloidosis, but its incremental benefit in the era of effective standard intensity therapy is unknown. We retrospectively analyzed 475 transplant‐eligible patients who completed standard intensity treatment with or without HDM ...
Maximilian J. Steinhardt, Ute Hegenbart, Tamer Hellou, Sara Oubari, Murielle Roussel, Rahel Schwotzer, Francis Buadi, David Dingli, Moritz Binder, Taxiarchis Kourelis, Saurabh S. Zanwar, Max J. Rieger, Caroline Morbach, Vladimir Cejka, Bernhard Gerber, Stefan Störk, Hermann Einsele, Shaji Kumar, Morie Gertz, Alexander Carpinteiro, K. Martin Kortum, Eli Muchtar, Angela Dispenzieri, Stefan Schönland   +23 more
wiley   +1 more source

Clinical Outcomes and Patient Experiences With Celiprolol Therapy in Vascular Ehlers–Danlos Syndrome: The First Non‐European Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder caused by heterozygous pathogenic variants in COL3A1. European studies have shown that celiprolol may reduce the risk of life‐threatening vascular events, but outcomes in non‐European populations and the therapy's psychological impact remain unclear. We conducted
Megumi Furuhata‐Yoshimura, Tomomi Yamaguchi, Tomoki Kosho   +2 more
wiley   +1 more source

Prediction of early postoperative major cardiac events after elective orthopedic surgery: the role of B-type natriuretic peptide, the revised cardiac risk index, and ASA class. [PDF]

, 2014
Background: The aim of this study was to evaluate pre- and post-operative brain natriuretic peptide (BNP) levels and compare the power of this test in predicting in-hospital major adverse cardiac events (MACE: atrial fibrillation, flutter, acute heart ...
Michele Divella, Paola Enrica Venchiarutti, Langiano N, Nicola Langiano, DELLA ROCCA, Giorgio, Araldo Causero, Vetrugno L, Renato Gisonni, Rizzardo A, Luigi Vetrugno, Giorgio Della Rocca, Gisonni R, Livia Pompei, CAUSERO, Araldo, Pompei L, Venchiarutti PE, Divella M, Alessandro Rizzardo   +17 more
core   +1 more source

Adverse Outcomes and Prediction of Cardiopulmonary Complications in Elective Spine Surgery

Global Spine Journal, 2018
Study Design: Retrospective cohort study. Objectives: The purpose of this study was to report incidence of cardiopulmonary complications in elective spine surgery, demographic and surgical predictors, and outcomes.
Peter G. Passias MD, Gregory W. Poorman BA, Edward Delsole MD, Peter L. Zhou BA, Samantha R. Horn BA, Cyrus M. Jalai BA, Shaleen Vira MD, Bassel Diebo MD, Virginie Lafage PhD   +8 more
doaj   +1 more source

Electrocardiographic and Skin Manifestations of Turner Syndrome: Association With Cardiovascular Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Congenital heart disease (CHD) and dermatologic conditions such as lymphedema and acquired melanocytic nevi (AMN) are common in Turner Syndrome (TS). We hypothesized that abnormalities of cranial neural crest cell derivatives drive the skin and heart manifestations of TS. We conducted joint cardiac and skin examinations of volunteers at a 2023
Sarah Elsaim, Brett Vernier, Van Thi Thanh Truong, Riya T. Patel, Matthew Brown, Martin Chacon Portillo, Megan Rogge, David Rodriguez‐Buritica, Siddharth K. Prakash   +8 more
wiley   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Polygenic Risk Scores in Myocardial Injury After Noncardiac Surgery

JACC: Advances
Background: Myocardial injury after noncardiac surgery (MINS) is the most prevalent vascular complication following surgical procedures. Although the revised cardiac risk index (RCRI) is widely used to predict postoperative cardiovascular complications ...
Ann Le, PhD, Guillaume Paré, MD, MSc, P.J. Devereaux, MD, PhD, Ibrahim Quazi, MSc, Shihong Mao, PhD, Michael Chong, PhD, Diane Heels-Ansdell, MSc, Emmanuelle Duceppe, MD, PhD, Michael Ke Wang, MD, Ameen Patel, MD, Maria Tiboni, MD, Patrick Magloire, MD, Amit X. Garg, MD, Sandra N. Ofori, PhD, David Conen, MD, Jessica Spence, MD, Emilie Belley-Côté, MD, PhD, Caleb Beck, MSc, William F. McIntyre, MD, PhD, Richard Whitlock, MD, PhD, Jeff S. Healey, MD, MSc, Shirley Pettit, RN, Flavia K. Borges, MD, PhD   +22 more
doaj   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source