Results 51 to 60 of about 1,522,172 (292)
Salud Uninorte, 2018 En las últimas décadas la investigación neurocientífica soporta el hecho de que las adicciones son enfermedades del cerebro, como la epilepsia o la enfermedad de Parkinson. El enfoque de manejar las adicciones de manera punitiva no ha arrojado resultados
Carlos Arturo Cassiani Miranda
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Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Cancer epidemiology and the workplace La epidemiología del cáncer y el ámbito de trabajo
Salud Pública de México, 1997 Occupational exposure occurs most frequently through direct contact with carcinogenic agents, with any of their active metabolites during absorption (skin, respiratory tract); or during excretion (urinary tract).
HOWARD FRUMKIN
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Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
PARES EVALUADORES: UNA CONSTANTE TRIBULACIÓN PARA LOS EDITORES DE REVISTAS INDEXADAS
Revista U.D.C.A Actualidad & Divulgación Científica, 2014 La mayoría de las publicaciones seriadas, colombianas y suramericanas, no cobran por página impresa, lo que dificulta lograr la evaluación por árbitros externos, cualificados y desinteresados.
Ingeborg Zenner de Polanía
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Ética del servidor público: revisión sistemática
, 2022 Ursula Alvarado Silva +1 more
openalex +2 more sources