Results 191 to 200 of about 32,388 (280)

Oxypaeoniflorin Ameliorates Titanium Particle‐Stimulated Osteolysis by Targeting Nrf2 to Reprogram Mitochondrial Homeostasis in Osteoclasts

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Wear debris surrounding implants plays a crucial role in the development of periprosthetic osteolysis (PPO) by inducing the aggregation of osteoclasts around the prosthesis. Oxypaeoniflorin (OPF), a derivative of Paeoniflorin, is primarily sourced from the root of the traditional Chinese medicine peony and possesses anti‐inflammatory and ...
Feng Zhu   +10 more
wiley   +1 more source

Inflammatory Pseudotumor After Total Hip Arthroplasty‐An Increasingly Recognized Complication

open access: yesOrthopaedic Surgery, Volume 18, Issue 7, Page 1311-1327, July 2026.
This review systematically elucidates the clinical characteristics and management of inflammatory pseudotumor (IP) across different bearing surfaces, addressing a topic of increasing concern and providing a novel perspective. It synthesizes the five primary risk factors associated with IP, offering clinicians critical reference points.
Steve T. L. Pambayi   +8 more
wiley   +1 more source

Is It Safe to Implant Prosthesis When Frozen Section Reports Positive During Joint Arthroplasty? A Retrospective Cohort Study

open access: yesOrthopaedic Surgery, Volume 18, Issue 7, Page 1342-1349, July 2026.
This study demonstrated that it is improper to overinterpret isolated frozen section positivity. It may be safe to implant prosthesis in patients who had positive frozen sections but without other signs of infection. Surgeons opting for staged revisions solely based on neutrophil counts risk unnecessary morbidity, particularly in patients with ...
Chiyuan Ma   +7 more
wiley   +1 more source

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

open access: yesThe FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu   +9 more
wiley   +1 more source

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