Results 61 to 70 of about 2,203 (211)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Unveiling Activation Process of C═N Cathode for High‐Performing Zinc‐Organic Batteries

Advanced Science, EarlyView.
A high‐performance organic cathode of DPPT has been designed for aqueous zinc‐ion batteries (ZIBs), showing ultralong cycle life of 45 000 cycles. Besides, flexible DPPT ZIBs with stable capacity are applied in wearable NH3 sensors. Notably, the activation mechanism of the transformation of DPPT‐eight proton into DPPT is proposed and proved which ...
Xiaodong Geng, Zhangyu Wang, Weiyao Bi, Qian Zhao, Hongting Ma, Kai Yang, Ying Liu, Zhiqian Li, Qinghua Deng, Dan Zhao, Yuqian Jiang, Nan Zhu   +11 more
wiley   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Revitalisation of spoil tips and socio-economic polarisation – a case study of Ruhr area (Germany)

Environmental & Socio-economic Studies, 2014
The paper discusses issues about the revitalisation of spoil tips, socio-economic polarisation and social exclusion in the field of municipal recreational activities based on an example of the largest post-industrial region in Europe – the Ruhr area in ...
Chmielewska Marta, Otto Marius
doaj   +1 more source

An integrated approach to river valley revitalisation

Journal of Environmental Engineering and Landscape Management, 2019
Rivers have always been a unique space in urban landscapes. Regrettably, the river-town relationship was disturbed in the 19th and at the beginning of the 20th century as industrial plants and districts were established at banks, which changed the urban ...
Maria Nawieśniak-Caesar, Magdalena Wilkosz-Mamcarczyk, Józef Hernik, Julia Gorzelany, Magdalena Gorzelany-Dziadkowiec   +4 more
doaj   +1 more source

Calcium‐Mechanochemistry Enabled Ketone Synthesis From Organic Iodides and Carboxylic Acids

Advanced Science, EarlyView.
Mechanochemically generated organocalcium species display unusual chemoselectivity toward carboxylates, enabling direct ketone synthesis without overaddition. Ball milling activates commercial calcium metal under ambient, solvent‐minimized conditions, providing a broad substrate scope, high functional‐group tolerance, and a practical one‐step ...
Mengyao Pei, Zekun Yang, Xueyan Yang, Yufang Yang, Yangyang Shen, Jiemin Wang, Peile Ma, Zezhu Li, Xiaoliang Zheng, Xiaofeng Wei   +9 more
wiley   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Revitalisation of cultural heritage and historical objects: from fragility to sustainable management in tourism

Mednarodno Inovativno Poslovanje
Purpose of the article – the paper examines the revitalisation of historic buildings, focusing on financial sustainability, community involvement, and regional development beyond mere technical renovation.
Gregor Jagodič, Vita Petek
doaj   +1 more source

A contribution to the research into the history of Zemun Cemetery and the possibilities for improving its current organisation [PDF]

Nasleđe, 2020
The focus of the academic subject themed The Protection and Revitalisation of Architectural Heritage in the academic 2019/2020 year was on defining the preservation of cultural, historical, architectural and urban-planning values of the spatial cultural ...
Petrović Danica M.
doaj  

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source