Results 31 to 40 of about 1,393,287 (284)

The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

eLife, 2020
GPR88 is an orphan G protein-coupled receptor (GPCR) considered as a promising therapeutic target for neuropsychiatric disorders; its pharmacology, however, remains scarcely understood.
Thibaut Laboute, Jorge Gandía, Lucie P Pellissier, Yannick Corde, Florian Rebeillard, Maria Gallo, Christophe Gauthier, Audrey Léauté, Jorge Diaz, Anne Poupon, Brigitte L Kieffer, Julie Le Merrer, Jérôme AJ Becker   +12 more
doaj   +1 more source

Neurodevelopmental Changes in Social Reinforcement Processing: A Functional Magnetic Resonance Imaging Study. [PDF]

, 2017
ObjectiveIn the current study we investigated neurodevelopmental changes in response to social and non-social reinforcement.MethodsFifty-three healthy participants including 16 early adolescents (age, 10-15 years), 16 late adolescents (age, 15-18 years),
Blair, James, Bookheimer, Susan Y, Hwang, Soonjo, Meffert, Harma, Sinclair, Stephen, VanTieghem, Michelle R, White, Stuart F   +6 more
core   +2 more sources

Feedback information and the reward positivity

, 2018
The reward positivity is a component of the event-related brain potential (ERP) sensitive to neural mechanisms of reward processing. Multiple studies have demonstrated that reward positivity amplitude indices a reward prediction error signal that is ...
Cockburn, Jeffrey, Holroyd, Clay
core   +1 more source

Teachers implementing Zimbabwean sign language regulatory frameworks for deaf learners in special schools

International Journal of Studies in Inclusive Education
Effective implementation of sign language-based instruction is crucial for providing quality education to Deaf learners at special schools. Teachers experienced challenges to effectively implement sign language policies for the Deaf learners in ...
Reward Kwashira
doaj   +1 more source

Mega-Reward: Achieving Human-Level Play without Extrinsic Rewards

, 2019
Intrinsic rewards were introduced to simulate how human intelligence works; they are usually evaluated by intrinsically-motivated play, i.e., playing games without extrinsic rewards but evaluated with extrinsic rewards.
Lukasiewicz, Thomas, Song, Yuhang, Wang, Jianyi, Wojcicki, Andrzej, Xu, Mai, Xu, Zhenghua, Zhang, Shangtong   +6 more
core   +1 more source

Dissociable effects of perceived control on reward-related neural dynamics under risk and ambiguity

NeuroImage
Perceived control plays a crucial role in risk-taking behavior, but its neural effect on reward dynamics in risky and ambiguous decision making remains unclear.
Shiting Chen, Menglin Wu, Jianbiao Zhao, Guanglong Liu, Wendeng Yang, Ya Zheng   +5 more
doaj   +1 more source

Endogenous opioid systems alterations in pain and opioid use disorder

Frontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham, Jessica A. Higginbotham, Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Nicolas Massaly, Nicolas Massaly, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón   +11 more
doaj   +1 more source

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

Modelling the Effect of Dorsal Raphe Serotonin Neurons on Patience for Future Rewards [PDF]

, 2016
Serotonin is a neurotransmitter that is implicated in many basic human functions and behaviours and is closely associated with happiness, depression and reward processing.
Porr, Bernd, Sutherland, Marc
core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source