Results 111 to 120 of about 3,150,678 (298)

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat [PDF]

, 1999
The main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area.
Kelley, Stephen P., Mittleman, Guy
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Neurobiologic Processes in Drug Reward and Addiction [PDF]

Harvard Review of Psychiatry, 2004
Neurophysiologic processes underlie the uncontrolled, compulsive behaviors defining the addicted state. These"hard-wired"changes in the brain are considered critical for the transition from casual to addictive drug use. This review of preclinical and clinical (primarily neuroimaging) studies will describe how the delineation between pleasure, reward ...
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Ranking of employees' reward and recognition approaces: A Malaysian Perspective [PDF]

Recognition of employees’ achievements is one of the most important factors to motivate employees. Employees who perform exceptionally well, expect that their contributions will be recognized or they will be appreciated by the top management.
Ismail, Ahmad Zaki, Islam, Rafikul
core  

Reward processing in gain versus loss context: An ERP study

, 2017
Previous research has shown that consummatory ERP components are sensitive to contextual valence. The present study investigated the contextual valence effect across anticipatory and consummatory phases by requiring participants to play a simple ...
Qi Li, Yuanyuan Zhang, Gao, Qianhui, Li, Qi, Zhang, Yuanyuan, Shiyu Zhou, Zhou, Shiyu, Shen, Huijuan, Huijuan Shen, Ya Zheng, Qianhui Gao, Zheng, Ya   +11 more
core   +1 more source

Sex and pubertal variation in reward-related behavior and neural activation in early adolescents

Developmental Cognitive Neuroscience
This study aimed to characterize the role of sex and pubertal markers in reward motivation behavior and neural processing in early adolescence. We used baseline and two-year follow-up data from the Adolescent Brain and Cognitive DevelopmentSM study ...
M.E.A. Barendse, J.R. Swartz, S.L. Taylor, J.R. Fine, E.A. Shirtcliff, L. Yoon, S.J. McMillan, L.M. Tully, A.E. Guyer   +8 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Effects of Learnability and Reward Responsiveness on Reward Processing

Abstract For methodological reasons, reward processing is commonly studied using random feedback and unlearnable tasks. It remains unclear whether task learnability influences reward-related brain activity, and whether this effect depends on individual differences such as reward responsiveness.
Abigail Oloriz, Olave E. Krigolson, Cameron D. Hassall   +2 more
openaire   +1 more source