Results 121 to 130 of about 3,150,678 (298)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Stimulus representation and the timing of reward-prediction errors in models of the dopamine system [PDF]

, 2008
The phasic firing of dopamine neurons has been theorized to encode a reward-prediction error as formalized by the temporal-difference (TD) algorithm in reinforcement learning.
Sutton, Richard S., Kehoe, E. James, Ludvig, Elliot Andrew   +2 more
core   +1 more source

Machine learning reveals differential effects of depression and anxiety on reward and punishment processing

Scientific Reports
Recent studies suggest that depression and anxiety are associated with unique aspects of EEG responses to reward and punishment, respectively; also, abnormal responses to punishment in depressed individuals are related to anxiety, the symptoms of which ...
Anna Grabowska, Jakub Zabielski, Magdalena Senderecka   +2 more
doaj   +1 more source

Neural response to monetary and social rewards in adolescent girls and their parents

NeuroImage
Functional magnetic resonance imaging (fMRI) studies have indicated that the mesocorticolimbic dopamine system is heavily involved in all stages of reward processing.
Rachel A. Ferry, Virja V. Shah, Jingwen Jin, Johanna M. Jarcho, Greg Hajcak, Brady D. Nelson   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Reward seeking and loss aversion: How effort, perception and monetary value influence the processing of reward and loss cues.

reservedThe study of decision-making has focused on variable aspects of the choosing process, along with its possible moderators, including, among others, rewards and losses, as individuals tend to make choices that maximise the former and minimise the ...
MOURATIDOU, THALEIA
core  

Neurotransmitter receptor gene expression patterns associated with reward-related neural representations

Neuroscience Research
The neural representation of reward is underpinned by neurotransmitter systems; however, current human neuroimaging techniques cannot assess the receptor-specific contributions to reward processing.
Kaosu Matsumori, Kana Matsuyanagi, Kenji Matsumoto   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Inverse Reinforcement Learning with Locally Consistent Reward Functions

, 2015
Existing inverse reinforcement learning (IRL) algorithms have assumed each ex-pert’s demonstrated trajectory to be produced by only a single reward function.
Low, Bryan Kian Hsiang, Quoc Phong Nguyen, Patrick Jaillet, Jaillet, Patrick, Kian Hsiang Low, Nguyen, Quoc Phong   +5 more
core  

Religiosity, financial risk taking, and reward processing: An experimental study [PDF]

The present study investigated the extent to which financial risk-taking (FRT) perspectives and religiosity influenced an individual's performance on financial decision-making tasks under risk and/or uncertainty.
Rashid, Mamunur, Griffiths, Mark D., Vadapalli, Sundara Kashyap, Kim, Amee, Vanheusden, F.   +4 more
core   +1 more source