Results 91 to 100 of about 189,749 (316)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Data Science JournalOpen Science contributes to the collective building of scientific knowledge and societal progress. However, academic research currently fails to recognise and reward efforts to share research outputs.
Laurence Mabile +5 more
doaj +1 more source
’Blessed are the Dead Which Die in the Lord’: Andrew Fuller on the Beatific Vision
Perichoresis: The Theological Journal of Emanuel University, 2019 This essay examines the funeral sermon given by the Baptist theologian Andrew Fuller (1754–1815) for his friend and deacon Beeby Wallis in 1792 as a vantage-point from which to pursue reflection on Fuller’s concept of heaven and the beatific vision.
Haykin Michael A. G., Burns E. D.
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Fighting Income Tax Evasion with Positive Rewards: Experimental Evidence [PDF]
This paper provides experimental evidence regarding the influence of positive rewards on income tax evasion behavior. In particular, we experimentally test the impact of positive rewards in form of individual lottery winnings for honest taxpayers.
Cécile Bazart, Michael Pickhardt
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After returning to education as a mature student, Ellie Workman reflects on the discomfort of growing pains during her time so far as a student paramedic, as well as the experience of reaping the rewards as she makes her way to the other side en route to
Workman, Ellie
core +1 more source
PROSPECTS FOR SHARIAH-COMPLIANT E-WALLET: ISSUES AND RECOMMENDATIONS
Malaysian Journal of Syariah and LawThe purpose of this study is to address the concept of e-wallet from a Sharīʿah perspective and its potential Sharīʿah concepts, issues, and challenges and to provide relevant recommendations to overcome those issues and challenges.
Abdul Muneem +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Responding to rewards and sanctions: the impact on students’ sense of belonging and school affect
, 2007 This qualitative study examines the impact of students’ interpretations and responses to rewards and sanctions on sense of belonging and school affect.
Mansfield, C.
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