Results 61 to 70 of about 29,933 (290)

Role of calcium desensitization in the treatment of myocardial dysfunction after deep hypothermic circulatory arrest [PDF]

, 2013
Introduction Rewarming from deep hypothermic circulatory arrest (DHCA) produces calcium desensitization by troponin I (cTnI) phosphorylation which results in myocardial dysfunction.
Faggian, Giuseppe, Giacomazzi, Alice, Hallström, Seth, Linardi, Daniele, Luciani, Giovanni, Mazzucco, Alessandro, Milani, Elisabetta, Rungatscher, Alessio, Scarabelli, Tiziano M, Tessari, Maddalena   +9 more
core   +3 more sources

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Rapid rewarming after therapeutic hypothermia worsens outcome in sepsis [PDF]

Clinical and Experimental Emergency Medicine, 2014
Objective This study was performed to investigate the effect of the rewarming rate on survival and acute lung injury in sepsis. Methods Male Sprague-Dawley rats underwent cecal ligation and incision. After 1 hour of sepsis induction, normothermia (37°C±0.
You Hwan Jo, Kyuseok Kim, Jae Hyuk Lee, Kwang Pil Rim, In Soo Cho   +4 more
doaj   +1 more source

Differential effects of slow rewarming after cerebral hypothermia on white matter recovery after global cerebral ischemia in near-term fetal sheep

Scientific Reports, 2019
It is widely believed that rewarming slowly after therapeutic hypothermia for hypoxic-ischemic (HI) encephalopathy can improve outcomes, but its impact on white matter injury after HI is unclear.
V. Draghi, G. Wassink, Kelly Q. Zhou, L. Bennet, A. Gunn, J. Davidson   +5 more
semanticscholar   +1 more source

Role of perfusion machines in the setting of clinical liver transplantation. A qualitative systematic review [PDF]

, 2018
Growing enthusiasm around machine perfusion (MP) in clinical liver transplantation (LT) may be the preamble for standardized practice to expand the donors' pool.
Lai, Quirino, Melandro, Fabio, Mennini, Gianluca, Pugliese, Francesco, Rossi, Massimo, Ruberto, Franco   +5 more
core   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Is prehospital use of active external warming dangerous for patients with accidental hypothermia: a systematic review

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2020
Background Optimal prehospital management and treatment of patients with accidental hypothermia is a matter of frequent debate, with controversies usually revolving around the subject of rewarming.
Sigurd Mydske, Øyvind Thomassen
doaj   +1 more source

An exploratory study into the effects of a 20 minute crushed ice application on knee joint position sense during a small knee bend. [PDF]

, 2016
Objectives The effect of cryotherapy on joint positioning presents conflicting debates as to whether individuals are at an increased risk of injury when returning to play or activity immediately following cryotherapy application at the knee.
Alexandra Carter, Algafly, Ben Oliver, Bennell, Bleakley, Bleakley, Bleakley, Bleakley, Bleakley, Bugaj, Cankar, Chesterton, Costello, Costello, Costello, Daniel Mee, Dover, Fishman, Ford, Hart, Herrera, Hewett, Hopper, James Selfe, Janwantanakul, Jill Alexander, Jim Richards, Jutte, Karen May, Kennett, Kiran, Knight, Krajnc, La Riviere, Malinzak, Michelle Scott, Mohammadi, Nadler, Olsson, Owens, Palastanga, Reurink, Ribeiro, Rice, Richards, Richards, Ruedl, Sargeant, Schepers, Selfe, Stillman, Surenkok, Thieme, Uchio, Vauhnik, Wassinger, Watanabe, Whatman, Williams, World Medical Association, Zazulak   +60 more
core   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

Gradual Rewarming with Gradual Increase in Pressure during Machine Perfusion after Cold Static Preservation Reduces Kidney Ischemia Reperfusion Injury. [PDF]

PLoS ONE, 2015
In this study we evaluated whether gradual rewarming after the period of cold ischemia would improve organ quality in an Isolated Perfused Kidney Model. Left rat kidneys were statically cold stored in University of Wisconsin solution for 24 hours at 4°C.
Paria Mahboub, Petra Ottens, Marc Seelen, Nils 't Hart, Harry Van Goor, Rutger Ploeg, Paulo N Martins, Henri Leuvenink   +7 more
doaj   +1 more source