Results 211 to 220 of about 231,693 (293)

High‐throughput, high‐fidelity reconstruction of whole mouse‐heart cytoarchitecture at cellular scale

The Journal of Physiology, EarlyView.
Abstract figure legend Experimental workflow of the dual‐camera light‐sheet microscope (dual‐mesoSPIM) pipeline. Intact adult mouse hearts undergo CUBIC‐based delipidation and refractive‐index matching, rendering the whole organ optically transparent (left).
Francesco Giardini, Chiara Palandri, Sofia Botti, Camilla Olianti, Paolo Mele, Niccolò Ballerini, Roberto Piersanti, Mauro Giacca, Peter Kohl, Callum M. Zgierski‐Johnston, Elisabetta Cerbai, Francesco Regazzoni, Leonardo Sacconi   +12 more
wiley   +1 more source

Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function. [PDF]

Mol Pharmacol
Nakhe AY, Dobson JR, Dadi PK, Westover D, Days EL, Vinson P, Weaver CD, Denton JS, Peachee SJ, Behera S, Gibson SE, Rodriguez Da Silva VA, Sela A, Dickerson MT, Jacobson DA.   +14 more
europepmc   +1 more source

Restoration of neuromuscular function by mitochondrial transplantation in injured mouse skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Mice received chemical injury (cardiotoxin) in the tibialis anterior muscle of one limb, and the contralateral muscle was injected with phosphate‐buffered saline (PBS) as a sham control. Mice then received PBS or mitochondria suspended in PBS into the tail vein.
Stephen E. Alway, Peter J. Ferrandi, Hector G. Paez, Christopher R. Pitzer, Junaith S. Mohamed, Michael R. Deschenes, James A. Carson   +6 more
wiley   +1 more source

Channelrhodopsin ion selectivity determines mechanisms and efficacy of optogenetic defibrillation in human atria and ventricles

The Journal of Physiology, EarlyView.
Abstract figure legend A, we used in silico models of human cardiomyocytes and microelectrode recordings on transgenic zebrafish hearts to study electrophysiology during optogenetic perturbations. Specifically, we compared effects of three distinct classes of channelrhodopsins: the cation non‐selective Chlamydomonas reinhardtii channelrhodopsin‐2 (ChR2)
Sophia Ohnemus, Albert Dasí, Ahmed F. Ramadan, Joachim Greiner, Eike M. Wülfers, Matthew R. Stoyek, Linda Tillert, Johannes Vierock, T. Alexander Quinn, Peter Kohl, Patrick M. Boyle, Viviane Timmermann, Franziska Schneider‐Warme   +12 more
wiley   +1 more source

Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal. [PDF]

Nat Commun
Oravetzova A, Dvorakova M, Mihai AI, Andrs M, Sobol M, Zuev A, Shukla K, Boleslavska B, Rosano V, König C, Prokes J, Hanzlikova H, Macurek L, Dobrovolna J, Janscak P.   +14 more
europepmc   +1 more source

ISWI/CHRAC orchestrates sequential chromatin-remodeling activities by mobilizing DNA polymerase ε for homologous recombination. [PDF]

Commun Biol
Qian J, Tanaka K, Yasui A, Ui A.
europepmc   +1 more source

Biological Flora of New Zealand 17: Kunzea ericoides (Myrtaceae), Kānuka

New Zealand Journal of Botany, Volume 64, Issue 4, December 2026.
This review summarises the taxonomic status, morphology, physiology, ecology, plant communities, mycological, invertebrate and vertebrate interactions and human use of the New Zealand endemic tree Kunzea ericoides (A. Rich.) Joy Thomps. (kānuka) (Myrtaceae).
P. J. Bellingham, M. S. McGlone, I. A. Dickie, N. Harcourt, P. B. Heenan, J. K. McCarthy, C. H. Watts, M. C. Smale, S. J. Richardson   +8 more
wiley   +1 more source

PKMYT1 has an important role in the timing and fidelity of chromosome segregation. [PDF]

EMBO Rep
Belbelazi A, Hendry AH, Trotter EW, Greenaway-Wells C, Edwards Z, Dawson K, Pines J, Hagan I.   +7 more
europepmc   +1 more source

The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Zedi Feng, Xiu Yin, Zhifang Jiang, Jia Yao, Yiling Dong, Xiaoxia Ma, Yijun Meng   +6 more
wiley   +1 more source

DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3' UTRs. [PDF]

Mol Cell
Suzawa M, Qiu C, Polash AH, Yamaji M, Jacob AA, Horikawa W, Farroha EM, Barua M, Feng X, Liu C, Williams JG, Randazzo D, Sartorelli V, Valkov E, Yamaji M, Hall TMT, Hafner M.   +16 more
europepmc   +1 more source