Results 241 to 250 of about 231,693 (293)

Retroviral adapters hijack the RNA helicase UPF1 in a CRM1/XPO1-dependent manner and reveal proviral roles of UPF1. [PDF]

Nucleic Acids Res
Prochasson L, Mghezzi-Habellah M, Roisin A, Palma M, Robin JP, de Bossoreille S, Cluet D, Mouelhi M, Decimo D, Desrames A, Chaze T, Matondo M, Dutartre H, Thoulouze MI, Lejeune F, Jalinot P, Rety S, Mocquet V.   +17 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation. [PDF]

Cell Rep
van Toorn M, Aslan M, Shintomi K, Yildiz A, Kiyomitsu T.   +4 more
europepmc   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Proximity labeling reveals non-catalytic interactions between DPP9 and ubiquitin signaling complexes. [PDF]

Cell Mol Life Sci
Wirtgen VE, Saied L, Zolg S, Alonso MC, Mayer B, Donzelli L, Maurer U, Timmers HTM, Knobeloch KP, Kleifeld O, Geiss-Friedlander R.   +10 more
europepmc   +1 more source

Modeling Catheter‐Associated Bladder Mucosal Adhesion and Microtrauma Using a Human Urothelial Microtissue Model

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley   +1 more source

Condensin IDC has a functional ATPase that is required for X-Chromosome dosage compensation in C. elegans. [PDF]

Genetics
Chawla B, Jatia S, Sloan D, Eduful J, Mendoza H, McClear CA, Tran J, Csankovszki G.   +7 more
europepmc   +1 more source

Emotional responses of veterinary students to first encounters with animal body donors

Anatomical Sciences Education, Volume 19, Issue 10, Page 1633-1648, October 2026.
Abstract Students' first encounters with animal body donors in higher education are a formative and also potentially stressful experience. The complex emotions elicited by body donor use in learning and their effects on professional development have been documented in medical students, but are far less explored in veterinary medical counterparts.
S. Regnault, C. Basu, S. Channon
wiley   +1 more source

Anti‐Inflammatory Effects of Vicatia thibetica De Boiss. in Rheumatoid Arthritis and Associated Multi‐Pathway Modulation In Vivo

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Vicatia thibetica de Boiss. (VTDB) extracts and fractions were screened for anti‐rheumatoid arthritis activity via UHPLC‐MS, network pharmacology, and CIA rat models. VTDB‐nBuOH stood out, regulating PI3K/Akt, JAK2/STAT3, macrophage polarization, and gut microbiota to relieve joint inflammation, with proteomics verifying its multi‐pathway regulatory ...
Mo‐Zi‐Li Adu, Wei Jiang, Min Li, Bo‐Wei Xia, En Yuan, Yue‐Zhi Tan, Wu‐Xin Yang, Guo‐Yue Zhong, Qin‐Ge Ma, Rong‐Rui Wei   +9 more
wiley   +1 more source

Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits. [PDF]

BMC Genomics
Wu J, Zhai J, Jia H, Ahamba IS, Dong X, Ren Z.   +5 more
europepmc   +1 more source