Results 31 to 40 of about 49,127 (197)

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism [PDF]

, 2014
Cornelia de Lange syndrome (CdLS) is a multisystem disorder with distinctive facial appearance, intellectual disability and growth failure as prominent features.
Aldridge, Roland, Green, Andrew J, Lampe, A., McKee, Shane A., Kingston, Helen, Kayserili, H., Bitner-Glindzicz, M, Chan, Cheng Yee, Kayserili, Hülya, Cooper, Nicola S, Mansour, S, Chandler, K, Ross, Alison, Bitner-Glindzicz, Maria, Ansari, M., Aldridge, R., Bennett, CP, Donnelly, D. E., Davidson, R, Chan, C. Y., Girisha, KM, Poke, G., Cook, J., Lampe, Anne K., Pilz, Daniela T, Chan, C., Poke, Gemma, Park, Soo-Mi, Ferry, Q., Lam, Wayne K, Cook, JA, Splitt, M., Johnson, Diana S., Wee, Jamie S., Deshpande, C, Falkenberg Smeland, Marie, Chan, CY, Avci, Şahin, Hurst, Jane A, Lam, W. K., Deshpande, C., Meynert, A., Bennett, C. P., Green, A. J., Donnai, D., Bengani, Hemant, Pilz, D. T., McEntagart, M, Thompson, Elizabeth M., Mansour, Sahar, Deshpande, Charu, McConnell, Vivienne, Davidson, Rosemarie, FitzPatrick, D. R., McEntagart, Meriel, Cooper, Nicola S., Thompson, E. M., Josifova, D., Holder, S. E., Green, Andrew J., Taylor, M. S., Homfray, Tessa, Kingston, H, FitzPatrick, DR, Tatton-Brown, Katrina, Hurst, J. A., Taylor, MS, Barnicoat, Angela, Magee, A. C., Parker, M. J., Wilson, L, Clayton-Smith, Jill, Flinter, F., Tolmie, J., Wee, J. S., Donnelly, Deirdre E., Lampe, Anne K, Fisher, Richard B, Green, AJ, Redeker, Egbert, Mehta, Sarju G, Hennekam, R. C. M., Prescott, K., Sisodiya, S., Mohammed, S., Wilson, Louise, Cox, H., Johnson, D. S., Mercer, C, Mohammed, S, Hennekam, RCM, Tatton-Brown, K, Redeker, E, Tolmie, John, Parker, Michael J., Meynert, Alison M, McEntagart, M., Vogt, Julie, Vogt, J, Chandler, K., Williamson, K., Fisher, R. B., Parker, M., et al., Magee, Alex C., Cox, H, Taylor, Martin S., Fryer, A, McKee, S. A., Ansari, M, Fryer, Alan, Firth, Helen V, Donnai, Dian, Firth, H. V., Hurst, JA, Lynch, Sally-Ann, Park, S-M, Brady, A. F., Behnam, Mahdiyeh, Cooper, N. S., Parker, MJ, Pilz, Daniela T., Harrison, V, Parker, Michael J, Wakeling, Emma, Behnam, M, Cooper, NS, Lampe, AK, Johnson, Diana S, Clayton-Smith, J., McKee, SA, McConnell, V, Homfray, T, Tolmie, J, McConnell, V., Lam, Wayne K., Barnicoat, A., Davidson, R., Firth, HV, Bennett, Christopher P, Ross, A, Donnelly, Deirdre E, Pilz, DT, Cilliers, D., Hennekam, Raoul C M, Taylor, Martin S; id_orcid, Falkenberg Smeland, M, Harrison, V., Holder, Susan E., Mercer, C., Brady, Angela F., Thompson, EM, Josifova, D, Stewart, Fiona, Harrison, Victoria, Lynch, SA, Smeland, Marie Falkenberg, Mehta, Sarju G., Wilkie, A, Wakeling, E., Firth, Helen V., Cilliers, Deirdre, Flinter, F, Girisha, Katta M., Splitt, Miranda, Meynert, A. M., Mehta, SG, Lam, WK, Homfray, T., Kayserili, H, Wee, Jamie S, Mohammed, Shehla, Cox, Helen, Bengani, H, Brady, Angela F, Donnelly, DE, Hennekam, RC, Barnicoat, A, Sisodiya, Sanjay, Ferry, Q, Kinning, Esther, Kinning, E., Fisher, Richard B., Wee, JS, Smeland, MF, Meynert, Alison M., Magee, Alex C, Brady, AF, Nellaker, C., Bitner-Glindzicz, M., Mansour, S., Holder, SE, Prescott, Katrina, Lynch, S-A, Cook, Jacqueline A, Williamson, Kathleen, Ruddy, D, Avci, S, Johnson, DS, Falkenberg Smeland, M., Stewart, F, Clayton-Smith, J, Lampe, A. K., Nellåker, C, Fryer, A., Smeland, M., Redeker, E., Girisha, K. M., Hurst, Jane A., Chandler, Kate, Avci, ahin, Nellåker, Christoffer, Lynch, S.-A., Ansari, Morad, FitzPatrick, David R, Wilson, L., Hennekam, Raoul C. M., Fitzpatrick, David R., Poke, G, Cilliers, D, Rosser, E., Ruddy, Deborah, Park, S.-M., Donnai, D, Wilkie, Andrew, Holden, Simon, Meynert, AM, Tatton-Brown, K., McKee, Shane A, Hennekam, R., Vogt, J., Magee, AC, Holder, Susan E, Ruddy, D., Aldridge, R, Williamson, K, Flinter, Frances, Mehta, S. G., Fisher, RB, Kinning, E, Park, SM, Prescott, K, Splitt, M, Josifova, Dragana, Girisha, Katta M, Holden, S., Rosser, E, Wakeling, E, Wilkie, A., Mercer, Catherine, Bengani, H., Ross, A., Kingston, H., Avci, Ş., Thompson, Elizabeth M, Rosser, Elisabeth, Cook, Jacqueline A., Ferry, Quentin, Sisodiya, S, Stewart, F., Behnam, M., Holden, S, Cook, J. A., Bennett, Christopher P.   +263 more
core   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Latent Profile Analysis of Challenging Behaviour in Individuals With Intellectual Disabilities: Examining Associated Factors and Life Satisfaction

British Journal of Learning Disabilities, EarlyView.
ABSTRACT Background Challenging behaviours (CBs) are known to adversely affect life satisfaction among individuals with intellectual disabilities. Little is known about the impact of different profiles of CBs amongst individuals with intellectual disabilities in South Korea.
Yesang Cho
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Reye\u27s syndrome: Are adults big children?

, 1988
Reye\u27s syndrome (RS) is generally considered a childhood disease. We report our experience with RS in adults in the metropolitan Milwaukee area. Reye\u27s syndrome was diagnosed in seven 18‐ to 46‐year‐old adults.
Latham, Patricia S.
core   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Neuroacanthocytosis Syndromes [PDF]

, 2011
Neuroacanthocytosis (NA) syndromes are a group of genetically defined diseases characterized by the association of red blood cell acanthocytosis and progressive degeneration of the basal ganglia.
Danek, Adrian, Hans H Jung, Walker, R H, Adrian Danek, Danek, A, Jung, Hans H., Walker, Ruth H., Jung, H H, Danek Adrian, Jung Hans H, Walker Ruth H, Ruth H Walker   +11 more
core   +1 more source

Reye syndrome and the value of electroencephalography in this syndrome

, 1988
İç organların yağlı dejenerasyon ile birlikte olan bir ensefalopati olarak tanımlanan Reye sendromu, bir çocukluk çağı hastalığı olarak kabul edilir. Reye sendromunun ülkemizde daha önceleri inandığı kadar az olmadığı inancındayız.

core   +1 more source

Sleep profiles in individuals with rare neurogenetic syndromes

Developmental Medicine &Child Neurology, EarlyView.
Aim To characterize sleep profiles in individuals with neurogenetic disorders (NGDs) and examine the contribution of key clinical and psychiatric symptoms to these profiles. Method The parents of 248 individuals (aged 3–45 years) diagnosed with a range of NGDs, including PTEN hamartoma tumor syndrome (n = 111), SYNGAP1‐related intellectual disability ...
Isabella C. Reyes, Thomas W. Frazier, Antonio Y. Hardan, Lacey Chetcuti, Samuel J. R. A. Chawner, Emily Spackman, Mirko Uljarević, Emma K. Baker   +7 more
wiley   +1 more source