Results 1 to 10 of about 22,259 (106)

Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. [PDF]

J Extracell Vesicles, 2023
Abstract Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication and promising biomarkers and therapeutics in the central nervous system (CNS). Human brain‐derived EVs (BDEVs) provide a comprehensive snapshot of physiological changes in the brain's environment, however, the isolation of BDEVs and the comparison of
Zhang Z, Yu K, You Y, Jiang P, Wu Z, DeTure MA, Dickson DW, Ikezu S, Peng J, Ikezu T.   +9 more
europepmc   +2 more sources

Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. METHODS We investigated the association of AD with both common variants and aggregates of rare coding and non‐coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data ...
Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Alzheimer's Disease Sequencing Project, Schellenberg GD, Destefano AL, Haines JL, Peloso GM.   +34 more
europepmc   +2 more sources

Compendium of proteins containing segments that exhibit zero‐tolerance to amino acid variation in humans

Protein Science, Volume 31, Issue 9, September 2022., 2022
Abstract Genetic missense tolerance ratio (MTR) analysis systematically evaluates all possible segments in a given protein‐encoding transcript found in the human population. This method scores each segment for the number of observed missense variants versus the number of silent mutations in that same segment.
Adam L. Sanders, Jake N. Hermanson, David C. Samuels, Lars Plate, Charles R. Sanders   +4 more
wiley   +1 more source

UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease

Advanced Science, Volume 9, Issue 7, March 4, 2022., 2022
Netrin‐1 is reduced in the brains of Parkinson's disease (PD) patients and PD genetic and neurotoxin mouse models, accompanied with prominent asparagine endopeptidase (AEP) activation and UNC5C fragmentation. Netrin‐1 deprivation in primary cultures induces AEP and caspase‐3 activation, triggering UNC5C fragmentation and neuronal loss.
Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye   +6 more
wiley   +1 more source

Otorhinolaryngology Out-Patient Practice in the “Post”-COVID-19 Era: Ensuring a Balance Between Service and Safety

Philippine Journal of Otolaryngology Head and Neck Surgery, 2020
Objective: To review available resources and provide evidence-based recommendations that may optimize otorhinolaryngologic out-patient health care delivery in the “post”-COVID-19 era while ensuring the safety of our patients, healthcare workers and staff.
Jose Florencio Lapeña, Franco Louie Abes, Mark Anthony Gomez, Cesar Vincent Villafuerte, Rodante Roldan, Philip Fullante, Ryner Jose Carrillo, Justin Elfred Lan Paber, Armando Isla, Rose Alcances-Inocencio, Jose Benedicto Cabazor, Ruzanne Caro, Ma. Fita Guzman   +12 more
doaj   +1 more source

Inflammatory Pseudotumor of the Maxillary Sinus

Philippine Journal of Otolaryngology Head and Neck Surgery, 2009
Inflammatory pseudotumor (IPT) is a rarely occurring lesion with no identifiable local or systemic cause. First described in 1905 by Birch-Hirschfield,1 it remains somewhat of an enigmatic disease entity despite multiple otolaryngologic, radiologic, and ...
Johann F. Castañeda, Jeffrey S. Concepcion, Ricardo L. Ramirez, Kirt Areis Delovino   +3 more
doaj   +1 more source

Plagiarism and Plunder: Fabrication and Falsification

Philippine Journal of Otolaryngology Head and Neck Surgery, 2010
“You, who are on the road Must have a code that you can live by And so, become yourself Because the past is just a good bye”1   The recent dismissal of charges of plagiarism made against no less than a Justice of the Supreme Court of the ...
Jose Florencio F. Lapeña
doaj   +1 more source

Postoperative Wound Complications in Modified Meatoplasty vs Z- Meatoplasty in Canal Wall Down Mastoidectomy at a Tertiary Hospital: A Randomized Controlled Trial

Philippine Journal of Otolaryngology Head and Neck Surgery, 2010
Objective: To compare the postoperative complications (narrowing of the enlarged canal and perichondritis) of a meatoplasty without conchal cartilage removal and more raw skin area (modified meatoplasty) versus a meatoplasty with conchal cartilage ...
Ma. Theresa L. Gumban, Natividad A. Almazan   +1 more
doaj   +1 more source

Typical Laryngeal Carcinoid Recurrence and its Management by Conservative Surgery

Philippine Journal of Otolaryngology Head and Neck Surgery, 2010
Objective: Recurrence of a typical laryngeal carcinoid is extremely rare after surgery with tumor-free margins on histopathology. We present a rare case of typical laryngeal carcinoid that recurred after eight years and was managed by conservative ...
Syed Majid Hussain, Rauf Ahmad
doaj   +1 more source

Feeding and Draining Vessel Ligation with Sclerotherapy of High Flow Arteriovenous Malformations in the Head and Neck

Philippine Journal of Otolaryngology Head and Neck Surgery, 2014
High flow arteriovenous malformations (AVMs) are infiltrative, invading tissue planes and structures and may be life threatening when they bleed.1 They have a feeding artery and an anomalous capillary bed shunting blood from the arterial system to the ...
Felixberto D. Ayahao
doaj   +1 more source