Results 1 to 10 of about 40,538 (153)

Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. [PDF]

J Extracell Vesicles, 2023
Abstract Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication and promising biomarkers and therapeutics in the central nervous system (CNS). Human brain‐derived EVs (BDEVs) provide a comprehensive snapshot of physiological changes in the brain's environment, however, the isolation of BDEVs and the comparison of
Zhang Z, Yu K, You Y, Jiang P, Wu Z, DeTure MA, Dickson DW, Ikezu S, Peng J, Ikezu T.   +9 more
europepmc   +2 more sources

Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. METHODS We investigated the association of AD with both common variants and aggregates of rare coding and non‐coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data ...
Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Alzheimer's Disease Sequencing Project, Schellenberg GD, Destefano AL, Haines JL, Peloso GM.   +34 more
europepmc   +2 more sources

Incidence of secondary atrophic rhinitis following endoscopic sinonasal tumour surgery: a retrospective review [PDF]

Rhinology Online, 2020
Background: Sinonasal tumours have been resected endoscopically at Groote Schuur Hospital, Cape Town, since 2003. The surgery, although called “minimally invasive” is often very aggressive and destructive to the nasal structures.
Mogammad S. Kamedien, Taseer F. Din, Darlene Lubbe   +2 more
doaj   +1 more source

Compendium of proteins containing segments that exhibit zero‐tolerance to amino acid variation in humans

Protein Science, Volume 31, Issue 9, September 2022., 2022
Abstract Genetic missense tolerance ratio (MTR) analysis systematically evaluates all possible segments in a given protein‐encoding transcript found in the human population. This method scores each segment for the number of observed missense variants versus the number of silent mutations in that same segment.
Adam L. Sanders, Jake N. Hermanson, David C. Samuels, Lars Plate, Charles R. Sanders   +4 more
wiley   +1 more source

UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease

Advanced Science, Volume 9, Issue 7, March 4, 2022., 2022
Netrin‐1 is reduced in the brains of Parkinson's disease (PD) patients and PD genetic and neurotoxin mouse models, accompanied with prominent asparagine endopeptidase (AEP) activation and UNC5C fragmentation. Netrin‐1 deprivation in primary cultures induces AEP and caspase‐3 activation, triggering UNC5C fragmentation and neuronal loss.
Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye   +6 more
wiley   +1 more source

Análise da dose vocal em pessoas cisgênero: resultados preliminares

Audiology: Communication Research, 2021
RESUMO Objetivo Verificar a diferença das medidas de frequência fundamental, intensidade e de dose vocal entre mulheres e homens cisgêneros, em situações de mesma demanda de voz. Métodos Trata-se de uma pesquisa observacional transversal.
Caroline de Lima, Alana Dantas Barros, Ana Cristina Côrtes Gama   +2 more
doaj   +2 more sources

Is Decline Rate of Intact Parathyroid Hormone Level a Reliable Criterion for Early Discharge of Patients after Total Thyroidectomy? [PDF]

Iranian Journal of Otorhinolaryngology, 2017
Introduction: Parathyroid dysfunction leading to symptomatic hypocalcemia is not uncommon following a total thyroidectomy and is often associated with significant patient morbidity and a prolonged hospital stay.
Mohsen Kolahdouzan, Shahab Shahabi Shahmiri, Seyed Mozafar Hashemi, Behrouz Kaleydari, Masoud Nazem, Rastin Mohammadi Mofrad   +5 more
doaj   +1 more source

Efeitos da estimulação gustativa na prontidão oral e estados comportamentais de recém-nascidos

Audiology: Communication Research, 2021
RESUMO Objetivo investigar e comparar comportamentos específicos de prontidão oral e estados comportamentais de recém-nascidos a termo (RNT) e pré-termo (RNPT), a partir da estimulação gustativa (água e sacarose). Métodos estudo experimental, analítico,
Andréa Monteiro Correia Medeiros, Vinicius do Nascimento Santi, Felipe Batista Santos, Thalyta Prata Leite de Sá, Íkaro Daniel Carvalho Barreto, Luana Ramos de Aquino, Stella Andrade Alves, Rogeris Kayque Barreto do Nascimento, Ricardo Queiroz Gurgel   +8 more
doaj   +2 more sources

Effect of topical corticosteroids on nasal patency after acute positive airway pressure exposure

Brazilian Journal of Otorhinolaryngology, 2021
Introduction: Nasal congestion and obstruction are reported in the majority of continuous positive airway pressure users and are frequently cited as reasons for noncompliance.
Leonardo Balsalobre, Aline Bruno Figueiredo, Rogério Pezato, Reginaldo Raimundo Fujita   +3 more
doaj  

Análise da fluência verbal semântica em idosos altamente escolarizados

Audiology: Communication Research, 2021
RESUMO Objetivo comparar o desempenho de idosos saudáveis com alta escolaridade nas análises quantitativas e qualitativas do Teste de Fluência Verbal Semântica, nas categorias ”animais” e ”frutas”, comparar o desempenho de subgrupos de participantes ...
Letícia Brincker, Emanuelle Mirlley Lima Pinheiro, Maysa Luchesi Cera, Corina Satler   +3 more
doaj   +2 more sources