Results 11 to 20 of about 63 (62)

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

open access: yesAdvanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung   +39 more
wiley   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

open access: yesAdvanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao   +6 more
wiley   +1 more source

Health System Factors in Head and Neck Cancer Diagnosis: A HEADSpAcE Consortium Qualitative Study in Glasgow and Montevideo

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Head and neck cancer (HNC) is a devastating diagnosis, with advanced‐stage disease leading to poorer outcomes. This qualitative study aimed to identify health system factors associated with stage of HNC diagnosis. Methods Qualitative semistructured interviews with HNC patients and clinicians were undertaken in two purposively ...
Grant Creaney   +196 more
wiley   +1 more source

HPV Serology and Circulating Viral DNA for Detection, Genotyping, and Measurement of Disease Burden in Oropharyngeal Cancer

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT The incidence of human papillomavirus‐positive (HPV+) oropharyngeal cancer (OPC) has increased rapidly, and HPV early antigen serology has been proposed as a scalable and cost‐effective early detection test. HPV seropositivity can precede clinical presentation of OPC by several years, so additional surveillance procedures may be necessary to ...
Lucas Penny   +23 more
wiley   +1 more source

Performance of Survival Prediction Tools in Patients With Gastrointestinal Stromal Tumors: A Systematic Review and Meta‐Analysis

open access: yesJournal of Surgical Oncology, EarlyView.
ABSTRACT Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We conducted a systematic review and meta‐analysis of studies that developed, validated, or updated clinical prognostic tools to predict survival in adults with primary GIST, identifying 47 eligible studies (38 development and 9 ...
Alice Zhu   +7 more
wiley   +1 more source

Identifying High‐Risk Children Safe for Same‐Day Discharge After Tonsillectomy

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Objective Current guidelines recommend overnight admission for children with severe obstructive sleep apnea (OSA) and obesity undergoing tonsillectomy, although most have uneventful postoperative courses. We aimed to identify low‐risk subgroups within this high‐risk population who may be candidates for same‐day discharge. Methods Retrospective
Amy Ho   +9 more
wiley   +1 more source

Depth of Invasion Predicts Vocal Fold Motility and Muscle Invasion in Glottic Carcinoma

open access: yesThe Laryngoscope, EarlyView.
To determine whether depth of invasion (DOI) provides an objective surrogate for vocal fold motility and vocal muscle invasion in glottic squamous cell carcinoma. Methods and Results: In derivation and external validation cohorts, radiologic DOI strongly correlated with pathologic DOI and accurately predicted altered vocal fold motility and muscle ...
Elisa Bellini   +22 more
wiley   +1 more source

Preoperative Neutrophil‐to‐Lymphocyte Ratio Predicts Recurrence in HPV‐Associated Oropharyngeal Cancer After Transoral Robotic Surgery

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Evaluate the role of preoperative neutrophil‐to‐lymphocyte ratio (NLR) as a predictor of survival outcomes after transoral robotic surgery (TORS) for human papillomavirus‐related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC).
Micah K. Harris   +12 more
wiley   +1 more source

The Prognostic Role of CD8+ Tumor‐Infiltrating Lymphocyte Density in Head and Neck Mucosal Melanoma

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To explore the prognostic role of CD8+ tumor‐infiltrating lymphocytes (TIL) density in head and neck mucosal melanoma (HNMM) using an automated, quantitative, immunohistochemistry‐based methodology. Study Design Retrospective cohort study. Setting Single‐institution, tertiary care hospital.
Nicholas K. Fung   +3 more
wiley   +1 more source

Pediatric Postoperative Acute Kidney Injury After Noncardiac Surgery: A Systematic Review and Meta‐Analysis

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Postoperative acute kidney injury (AKI) is associated with substantial morbidity and mortality. Reliable estimates of AKI after surgery in children are lacking. To address this gap, we aimed to synthesize the available evidence on the incidence of AKI after pediatric noncardiac surgery.
Arash Emami   +6 more
wiley   +1 more source
machine learning
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