Results 121 to 130 of about 396 (138)

Effects of Cyclization on Stability, Structure, and Activity of α-Conotoxin RgIA at the α9α10 Nicotinic Acetylcholine Receptor and GABA_B Receptor

Journal of Medicinal Chemistry, 2011
α-Conotoxin RgIA is of interest as a lead in the development of drugs for neuropathic pain. It modulates the α9α10 nicotinic acetylcholine receptor (nAChR) and the GABA(B) receptor, both of which are implicated in antinociception. However, because of its peptidic nature, RgIA is potentially susceptible to generic problems encountered by peptide-based ...
Halai, Reena, Callaghan, Brid, Daly, Norelle L., Clark, Richard J., Adams, David J., Craik, David J.   +5 more
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THE HISTORY OF THE TUBA IN RUSSIA: RESEARCHER A.R. LEVASHKIN’S STUDY EXPERIENCE OF THE MATERIALS OF RGIA AND GARF

History and Archives, 2019
The article is devoted to the experience of using the funds of Russian archives by researcher Alexey Romanovich Levaskin. He was a professional orchestral soloist – a tubist with a wide experience of diverse orchestral practice. A touring musician and the soloist of the orchestra, the researcher for several years dedicated all his free time to the ...
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The story of alpha-conotoxins, Vc1.1 and RgIA, on their journey to becoming therapeutics [PDF]

, 2009
Abstract The broad aim of this thesis is to structurally and functionally explore two α-conotoxins, from venomous sea snails, Vc1.1 and RgIA, in the hope of improving their journey to becoming analgesic therapeutics (introduction to conotoxins in Chapter 1).
openaire  

Dissecting oxidative folding of conotoxins using 3D structures of cysteine mutants predicted by AlphaFold 3: A case study of α-conotoxin RgIA, χ-conotoxin CMrVIA and ω-conotoxin MVIIA-Gly

Toxicon
The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins. The peptides α-conotoxin RgIA (α-RgIA) and χ-conotoxin CMrVIA (χ-CMrVIA) share a similar cysteine pattern but differ in their native disulfide connectivity.
K, Radhakrishna, Patil Kanchan, Rajshekhar, R, Arshitha, Kashibai, Patil, Shweta, Dhannura, Konkallu Hanumae, Gowd   +5 more
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α-conotoxin RgIA analogs and the treatment of neuropathic pain

Toxicon, 2019
J. Michael McIntosh, Haylie Romero, Sean Christensen, Cheryl Dowell, Shawn Iadonato, Jose Mercado, Baldomero M. Olivera   +6 more
openaire   +1 more source

Detection of the binding sites for conotoxins RgIA and GeXIVA with two cholinoreceptor models

Toxicon, 2019
Elena Kryukova, Igor Ivanov, Dmitry Lebedev, Ekaterina Spirova, Natalia Egorova, Marios Zouridakis, Igor Kasheverov, Socrates Tzartos, Victor Tsetlin   +8 more
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From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR

Marine Drugs, 2021
Si Pan, Xiaopeng Zhu, Yi Xue
exaly  

Building Infrastructure through PPP Model: Policy Lessons from RGIA

Indian Journal of Public Administration, 2008
A. Viswanath, C. Jeevan Kumar
openaire   +1 more source

Analgesic alpha-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of alpha9 nicotinic receptor knockout mice

2010
Alpha-conotoxins Vc1.1 and RgIA are peptides from the venom of marine Conus snails that are currently in development as a treatment for neuropathic pain. We have reported previously that the alpha9alpha10 nicotinic acetylcholine receptor (nAChR) selective-conotoxins Vc1.1 and RgIA potently and selectively inhibit high voltage-activated (HVA) N-type ...
Callaghan, Brid, Adams, David J.
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Dicarba modification of α-conotoxin RgIA conferring selectivity towards α9α10 nicotinic acetylcholine receptors

Biochemical Pharmacology, 2013
S.N. Kompella, B.J. van Lierop, S.D. Robinson, A. Belgi, B. Callaghan, A. Hung, C.A. MacRaild, R.S. Norton, A.J. Robinson, D.J. Adams   +9 more
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