Results 121 to 130 of about 409 (143)
α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement [PDF]
Pain, 2014 Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prevent nervous tissue alterations ...
Lorenzo Di Cesare Mannelli +2 more
exaly +4 more sources
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Journal of Molecular Graphics and Modelling, 2019
The α9α10 nicotinic acetylcholine receptor (nAChR) is an effective therapeutic target for neuropathic pain. α-Conotoxin RgIA and Vc1.1 are two well-known peptides blocking α9α10 nAChR potently and selectively, which have been extensively investigated as drug candidates. Several key residues were established in previous experimental research.
Sulan Luo
exaly +3 more sources
The α9α10 nicotinic acetylcholine receptor (nAChR) is an effective therapeutic target for neuropathic pain. α-Conotoxin RgIA and Vc1.1 are two well-known peptides blocking α9α10 nAChR potently and selectively, which have been extensively investigated as drug candidates. Several key residues were established in previous experimental research.
Sulan Luo
exaly +3 more sources
Journal of Medicinal Chemistry, 2011
α-Conotoxin RgIA is of interest as a lead in the development of drugs for neuropathic pain. It modulates the α9α10 nicotinic acetylcholine receptor (nAChR) and the GABA(B) receptor, both of which are implicated in antinociception. However, because of its peptidic nature, RgIA is potentially susceptible to generic problems encountered by peptide-based ...
Halai, Reena +5 more
openaire +5 more sources
α-Conotoxin RgIA is of interest as a lead in the development of drugs for neuropathic pain. It modulates the α9α10 nicotinic acetylcholine receptor (nAChR) and the GABA(B) receptor, both of which are implicated in antinociception. However, because of its peptidic nature, RgIA is potentially susceptible to generic problems encountered by peptide-based ...
Halai, Reena +5 more
openaire +5 more sources
History and Archives, 2019
The article is devoted to the experience of using the funds of Russian archives by researcher Alexey Romanovich Levaskin. He was a professional orchestral soloist – a tubist with a wide experience of diverse orchestral practice. A touring musician and the soloist of the orchestra, the researcher for several years dedicated all his free time to the ...
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The article is devoted to the experience of using the funds of Russian archives by researcher Alexey Romanovich Levaskin. He was a professional orchestral soloist – a tubist with a wide experience of diverse orchestral practice. A touring musician and the soloist of the orchestra, the researcher for several years dedicated all his free time to the ...
openaire +1 more source
The story of alpha-conotoxins, Vc1.1 and RgIA, on their journey to becoming therapeutics [PDF]
, 2009 Abstract The broad aim of this thesis is to structurally and functionally explore two α-conotoxins, from venomous sea snails, Vc1.1 and RgIA, in the hope of improving their journey to becoming analgesic therapeutics (introduction to conotoxins in Chapter 1).
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Toxicon
The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins. The peptides α-conotoxin RgIA (α-RgIA) and χ-conotoxin CMrVIA (χ-CMrVIA) share a similar cysteine pattern but differ in their native disulfide connectivity.
K, Radhakrishna +5 more
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The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins. The peptides α-conotoxin RgIA (α-RgIA) and χ-conotoxin CMrVIA (χ-CMrVIA) share a similar cysteine pattern but differ in their native disulfide connectivity.
K, Radhakrishna +5 more
openaire +2 more sources
α-conotoxin RgIA analogs and the treatment of neuropathic pain
Toxicon, 2019J. Michael McIntosh +6 more
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Building Infrastructure through PPP Model: Policy Lessons from RGIA
Indian Journal of Public Administration, 2008A. Viswanath, C. Jeevan Kumar
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Detection of the binding sites for conotoxins RgIA and GeXIVA with two cholinoreceptor models
Toxicon, 2019Elena Kryukova +8 more
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