Results 31 to 40 of about 409 (143)

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

British Journal of Pharmacology, Volume 178, Issue S1, Page S157-S245, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Alistair Mathie, John A Peters, Emma L Veale, Jörg Striessnig, Eamonn Kelly, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Richard W. Aldrich, Bernard Attali, Austin M Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, William A. Catterall, Alex C. Conner, Paul Davies, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Chandy George, Steve A. N. Goldstein, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Mike Jarvis, Anders A. Jensen, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Joseph W. Lynch, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Lixia Yue, Xiaoli Zhang, Michael Zhu   +57 more
wiley   +1 more source

Письма А.Ф. Малиновского (1800-е гг.) как попытка автобиографии

Avtobiografija, 2020
This article analyses the correspondence by Aleksei Fedorovich Malinovskii (1762–1840) from the point of view of his strategy of creating his new self as an authentic nobleman.
Maia Lavrinovich
doaj   +1 more source

Riots in Svisloch Gymnasium: Persecution of Secret Societies among Polish-Lithuanian Youth

Научный диалог, 2023
The article deals with the riots in the Svisloch gymnasium that occurred after the closure of the trial of the Philarets and Philomaths (1824), which was initiated by N. N.
K. B. Egorova
doaj   +1 more source

Limited Efficacy of α-Conopeptides, Vc1.1 and RgIA, To Inhibit Sensory Neuron Ca_VCurrent [PDF]

eneuro, 2015
AbstractChronic pain is very difficult to treat. Thus, novel analgesics are a critical area of research. Strong preclinical evidence supports the analgesic effects of α-conopeptides, Vc1.1 and RgIA, which block α9α10 nicotinic acetylcholine receptors (nAChRs). However, the analgesic mechanism is controversial.
Andrew B, Wright, Yohei, Norimatsu, J Michael, McIntosh, Keith S, Elmslie   +3 more
openaire   +2 more sources

DOCUMENTARY MATERIALS ABOUT P.K. ESSEN (1772-1844) IN THE FUNDS OF THE RUSSIAN STATE HISTORICAL ARCHIVES

Вестник Брянского государственного университета, 2022
The article provides a brief overview of the most important documents on the activities of the Vyborg and Orenburg military Governor, St. Petersburg Military Governor-General, General of Infantry, Count P.K.
Bogdanova T.V.
doaj   +1 more source

Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors. [PDF]

J Med Chem, 2020
Non-opioid therapeutics for the treatment of neuropathic pain are urgently needed to address the ongoing opioid crisis. Peptides from cone snail venoms have served as invaluable molecules to target key pain-related receptors but can suffer from unfavorable physicochemical properties, which limit their therapeutic potential.
Zheng N, Christensen SB, Blakely A, Dowell C, Purushottam L, McIntosh JM, Chou DH.   +6 more
europepmc   +4 more sources

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models

Marine Drugs, 2018
α-Conotoxins from Conus snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). α-Conotoxin RgIA and αO-conotoxin GeXIVA, blocking neuronal α9α10 nAChR, are potential analgesics ...
Elena V. Kryukova, Igor A. Ivanov, Dmitry S. Lebedev, Ekaterina N. Spirova, Natalia S. Egorova, Marios Zouridakis, Igor E. Kasheverov, Socrates J. Tzartos, Victor I. Tsetlin   +8 more
doaj   +1 more source

Fight for Sobriety in Russia at Beginning of 20th Century: Discussion on Low-Alcohol Beverages

Научный диалог, 2023
The problem of alcohol consumption and the struggle for sobriety in Russia in the early 20th century is being investigated. The discussion in government and public circles about the possibility of effectively combating drunkenness by spreading the ...
I. A. Shevchenko, L. I. Zemtsov
doaj   +1 more source

Archival Heritage of Solovyov V.S. in Russia: Analytical Review

RUDN Journal of Philosophy, 2023
The study is devoted to the study of actual state of the archival materials of V.S. Solovyov which are held in different funds of Russia. During the working process was carried out the analysis of Solovyov’s related materials in a number of archives of ...
Aleksandra Yu. Berdnikova
doaj   +1 more source

Chief Procurator S. M. Lukyanov and His Proposals on Improving the Control and Auditing Activities of the Educational Committee under the Holy Synod [PDF]

Вестник Екатеринбургской духовной семинарии, 2022
The article analyzes the activities of Chief Procurator of the Holy Synod Sergei Mikhailovich Lukyanov to improve the work of the Educational Committee under the Holy Synod in general and its control and auditing activities in particular.
Hieromonk Therapont (Shirokov)
doaj   +1 more source