Results 21 to 30 of about 396 (138)
On the issue of studying Siberian merchant class: the circle of social contacts of gold producer Yakov Frizer [PDF]
Омский научный вестник: Серия "Общество. История. Современность", 2020 The research is dedicated to Siberian merchant Yakov Frizer, a range of his communication and social contacts. Present research targets to illustrate through Frizer example particularities of everyday life and activity of the Siberian merchants on the
I. Vladimirsky, M. V. Krotova
doaj +1 more source
On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. [PDF]
Aust J Chem, 2020 In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we established facile access to grams of Cy5-COOH via a two-step synthetic route, demonstrated that Cy5 is stable to HF ...
Muttenthaler M +5 more
europepmc +8 more sources
Molecular Interaction of α-Conotoxin RgIA with the Rat α9α10 Nicotinic Acetylcholine Receptor [PDF]
Molecular Pharmacology, 2015 The α9α10 nicotinic acetylcholine receptor (nAChR) was first identified in the auditory system, where it mediates synaptic transmission between efferent olivocochlear cholinergic fibers and cochlea hair cells. This receptor gained further attention due to its potential role in chronic pain and breast and lung cancers.
Azam, Layla +5 more
openaire +3 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +72 more
wiley +1 more source
Lower‐Class Reading in Late Imperial Russia
The Russian Review, Volume 82, Issue 4, Page 649-667, October 2023., 2023 Abstract This article demonstrates widespread engagement of lower‐class people with the written word in the late nineteenth and early twentieth century Russian Empire, in rural and urban locales, in homes, workplaces, and social spaces. We explore how lower‐class people read: the daily habits, personal relationships, and social spaces that shaped ...
Sarah Badcock, Felix Cowan
wiley +1 more source
Novos Cadernos NAEA, 2021 O presente artigo tem como objetivo abordar a expansão e as implicações socioespaciais do eucalipto na Região Geográfica Intermediária de Araguaína (RGIA), tomando como base teórica o pensamento de Milton Santos quanto ao meio técnico-científico ...
Luciano da Silva Guedes +1 more
doaj +1 more source
School, Empire, and the Provincial Roots of Civil Activism in Late Nineteenth‐Century Russia
The Russian Review, Volume 82, Issue 4, Page 668-681, October 2023., 2023 Abstract In spring 1879, news reached the Russian Ministry of Education that students from several Real Schools in the Russian Empire’s western provinces were planning to send a coordinated petition to the Minister of Education, asking for permission to enroll in university. The petition initiative was arranged in secrecy and involved more than a dozen
Alex Valdman
wiley +1 more source
On the biography of Vladimir Gippius [PDF]
Литературный факт, 2020 The paper provides archival and little-known materials that extend the information on the early period of Vladimir Gippius’ biography. In letters to his acquaintance, Matilda Menzel, he shares his thoughts on A.M.
Yulia Rykunina
doaj +1 more source
Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors. [PDF]
J Med Chem, 2020 Non-opioid therapeutics for the treatment of neuropathic pain are urgently needed to address the ongoing opioid crisis. Peptides from cone snail venoms have served as invaluable molecules to target key pain-related receptors but can suffer from unfavorable physicochemical properties, which limit their therapeutic potential.
Zheng N +6 more
europepmc +4 more sources
Dilation, Steroid Injection, and Cough Exercise for Correction of Posterior Glottic Stenosis
The Laryngoscope, Volume 133, Issue 4, Page 883-889, April 2023., 2023 DISCO (Dilation, Steroid injection and post‐operative Cough Exercise) is a novel protocol for correcting posterior glottic stenosis. Post‐op cough acts as physical‐therapy to improve motion and flexibility. It can restore mobility and expand glottic airway without insufficiency. Objective To describe the DISCO protocol (Dilation, Steroid injection, and
Hagit Shoffel‐Havakuk +5 more
wiley +1 more source