Substitution of D-Arginine at Position 11 of α-RgIA Potently Inhibits α7 Nicotinic Acetylcholine Receptor [PDF]
Marine Drugs, 2023 Conotoxins are a class of disulfide-rich peptides found in the venom of cone snails, which have attracted considerable attention in recent years due to their potent activity on ion channels and potential for therapeutics.
Xiaopeng Zhu, Sulan Luo, Yong Wu
exaly +6 more sources
Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors [PDF]
Frontiers in Pharmacology, 2019 The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in heteropentameric assemblies with α10. Accumulating data indicate the presence of three different binding sites in α9α10 nAChRs: the α9(+)/α9(−), the α9(+)/α10(−), and the α10(+)
Marios Zouridakis +2 more
exaly +7 more sources
Engineering Enhanced Antimicrobial Properties in α-Conotoxin RgIA through D-Type Amino Acid Substitution and Incorporation of Lysine and Leucine Residues [PDF]
MoleculesAntimicrobial peptides (AMPs), acknowledged as host defense peptides, constitute a category of predominant cationic peptides prevalent in diverse life forms. This study explored the antibacterial activity of α-conotoxin RgIA, and to enhance its stability
Sulan Luo, Yong Wu
exaly +6 more sources
Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells [PDF]
Frontiers in Cellular Neuroscience, 2021 Efferent cholinergic neurons inhibit sensory hair cells of the vertebrate inner ear through the combined action of calcium-permeable α9α10-containing nicotinic acetylcholine receptors (nAChRs) and associated calcium-dependent potassium channels.
Fernando Fisher +9 more
doaj +5 more sources
Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism [PDF]
Marine Drugs, 2022 Conus regius is a marine venomous mollusk of the Conus genus that captures its prey by injecting a rich cocktail of bioactive disulfide bond rich peptides called conotoxins.
Francesco Margiotta +5 more
doaj +2 more sources
From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR [PDF]
Marine Drugs, 2021 α9-containing nicotinic acetylcholine receptors (nAChRs) have been shown to play critical roles in neuropathic pain. The α-conotoxin (α-CTx) RgIA and its analog RgIA4 were identified as the most selective inhibitor of α9α10 nAChR.
Si Pan +5 more
doaj +2 more sources
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins [PDF]
Marine Drugs, 2023 Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond.
Bankala Krishnarjuna +9 more
doaj +2 more sources
RgIA4 Prevention of Acute Oxaliplatin-Induced Cold Allodynia Requires α9-Containing Nicotinic Acetylcholine Receptors and CD3+ T-Cells [PDF]
Cells, 2022 Chemotherapy-induced neuropathic pain is a debilitating and dose-limiting side effect. Oxaliplatin is a third-generation platinum and antineoplastic compound that is commonly used to treat colorectal cancer and commonly yields neuropathic side effects ...
Peter N. Huynh +2 more
doaj +2 more sources
Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors [PDF]
Frontiers in Pharmacology, 2022 In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux through the central channel of the receptor.
Arik J. Hone +4 more
doaj +2 more sources
Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms [PDF]
Frontiers in Cellular Neuroscience, 2021 Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits.
Victor Tsetlin +11 more
doaj +2 more sources