Results 91 to 100 of about 122,023 (220)
Structural and organisational impacts of peri‐operative enhanced care services in the UK: a Retrospective Evaluation of Postoperative Alternatives to Critical Care (REPACC)
Anaesthesia, EarlyView.Summary Introduction
The enhanced care model of peri‐operative care has evolved to meet increasing surgical demand, aiming to relieve pressure on critical care and prevent unnecessary cancellation of surgery. Despite widespread adoption of these facilities in the UK, no resources currently describe the national landscape of enhanced care or the ...Christopher Oddy, Dominic Lowcock, Thomas W. Davies, Sarah Towey, Mark Burnett, Amanda Davis, Gareth Davey, Adam Green, Olivia Bools, Michael Coulton, Henry Lewith, Paolo Perella, Danny J. N. Wong, the Pan‐London Perioperative Audit and Research Network Committee, the REPACC Study Investigators, Mohamed Hussein, Kazi Farhana Akhter, Konye Anthonia Ochonogor, Tanya Elizabeth Spencer, Nicky Carroll, Zain Malik, Anja Sabine Daniela Kuttler, Madeleine Gray, Cathy Zhang, Marie Smith, Snehal Kale, Sumeet Gajbhar, Nathalie Stevenson, Jennifer Mullan, Joshua Hulman, Ken Inweregbu, Juan Michael Jansen van Vuuren, Jatinder Stanley, Arun Sahni, Caroline Phillips, Lara Allen, Jessica Hickman, Georgina Singleton, Lisa Grimes, Simon Chung Yan Lam, Dinesh Tumu, Gayatri Khanvelkar, Rohit Patil, Prasad Lanka, James Womersley, Emma Smith, Helen Köwitz Arroyo, Jahnavi Priya, Dafydd Lloyd, Ceit Cunningham, Richard Snooks, Aimi Lara Emilie Jeanes, Lara Jeanes, Tamsyn Glover, Roger Davies, Emily J Croft, Nipun Agarwal, Thomas Craven, Barnaby Dykes, Gianfranco Messina, Islam Abousharkh, James Brown, Sarah Kipling, Sodha Meera, Stephanie Davis, Maria Chereshneva, Sundar Raj Ashok, Craig Morris, Thomas Bacarese‐Hamilton, Jack Gallagher, Nicola K Pearson, Katarzyna Anna Marasinska, William Roberts, Vikram Singh, Benjamin Ledsom, Bhavna Bhalla, Sioned Phillips, David Bailey, Jacob Lawson, Adriano Ferrante, Aldo Alberto Bignamini, Adam Beebeejaun, David Bailey, Georgia Boniface, Jen VanRoss, Larissa Matveeva, Sherpal Singh, Soo Yoon, Zhi Yap, Divya Gautam, Omnia Askar, Sanooj Soni, Priyanka Tewari, Ankita Deshpande, Kimberly Kok, Neil Gaurav Verma, Nigel West, Tanumoy Maulick, John Robson, Ikechukwu Igwebuike, Balaji Rajamani, Fionnuala Durrant, John McDonald, Jude Spedding, Leo Worley, Ritoo Kapoor, Ivana Kaljevic, Sarah Brown, Benedicte Sjoflot, Sanya Patel, Akshay Pradhan, Arif Ahmed, Ee Lyn Chan, Jenny Olsson, Ravi Bhatia, Marie Harrison, Michael Burnley, Deepak Subramani, Rachel Holmes, Moh’d Adnan Hasan Yousef, Lucy Marshall, Rebecca King, William Flinn, Ayman Salmona, Hisham Mohamed Riad, Prajith Sanjeewa Amarasekara, Ruth Charlesworth, Valeria Ortiz Martinez, Zahid Furqan, Alix Gerard, Louise White, Catherine Moriarty, Caroline Thomas, Benjamin Kidner, Benjamin Kidner, Rebecca Holyland, Varun Aggarwal, Talia Wieder, Gursimren Lidder, Robert Connolly, Pietro Ferranti, Camila Maria de Oliveira, Manju Sharma, Meithem Ali, Amy Ackerley, Rebecca Seaman, Kate Stannard, James Wood, Eslam Elsayed, Arun Prasad Ravichandran, Prerna Shaktawat, Rashid Hussain, Samyuktha Raj, Yousuf Abusamra, Gareth Kitchen, Alexander Fowler, Ameila Milton, Chloe Start, Adam Mills, Benjamin Hofland‐Ward, George Humble, Kate Preston, Matthew Smith, Milena Vannahme, Brendan Sloan, Catherine Chapman, Helen Ivatt, Steve Davies, Tristan Edey, Nia Wyn Davies, Justin Maini, Thomas Hirst, Dona Saha, Drew Harding, Gilbert Thomas‐Black, Georgia Mathieson, Francis Elechi, Kavita Patel, Maia Shivani Yashwini Back, Freddie Weyman, Ketan Kataria, Thomas Fowler, Bhavesh Gohil, Rohit Hanmanta Bhandari, Sonali Gupta, AlexKumar Patel, Kritika Rathour, Rohit Rohit, Estelle Maria D'Cunha, Ammara Khan, Anjali Ashok Menon, Arun Thirunavukarasu, Mansi Gandhi, James Goetz, Maria Pikoula, Menaka Iyer, Sarah Hudson, Shweta Appiah, Sophie Ledsome, Kirstin Strathie, Tejal Kothari, Yashasvi Perera, James Day, Alexander Johnson, Adam Phillips, Elin Rowlands, Elizabeth Grant, Jessica Phillips, Anna Forbes, Thomas Reed, Joseph A Gallaher, Rebecca Mitchell, Hayley Kaye, Charlene Barter, Tamer Younes, Moustafa Zahra, Sameer Qasala, Sajith Damodaran, Hannah Nugent, Mandeep Phull, Adam J Boulton, Ahmed Ibrahim, Brigitte Baxter, Orla Gillman, Sejal Modasia, Graham Bolton, Karthik Iyer, Michael P Coulton, Paul Bramley, Aaron Owen, Jonathan Emberey, Anil Hormis, Clare Windsor, Rebecca Murphy, Ana Orozco, Maxime Gibbons, Robin Helsby, Arun Mohanraj, Alexandra Gray‐Renfrew, Alison Thorne, Elizabeth Whittaker, Jesymin Jia Min Choong, Vikram Nagarajan, Anuradha Kurvey, Claire Pollington, Saadia Shahzad, Stephanie Alsop, Madhu Balasubramaniam, Eleanor Shaw, Rachel Grant, Alexandra Cockroft, David Ivan Wells, Isabel Greaves, Oliver Eastwood, Judith Cheong‐Leen, Thomas Capstick, Urbi Sen, Leanne Darwin, Uneesa Mahmood, Alastair Savage, Adedolapo Adejumo, Sam Murgatroyd, John Mensah, Victoria Lowden, Alex Chatburn, Christopher Harrison, Erica Morris, Jake Winterbottom, Samuel Allen, Viren Kadodwala, Matthew Needham, Matthew Holland, Matthew Holland, Eleanor Lewis, Gareth Ifan James Davey, Nicoletta Fossati, Hannah Gardiner, Prateek Nalwaya, Adyasha Das, Duncan Baily, Cindy Luximon, Alex Wickham, James Heggie, Aamer Mughal, Daniel Greaves, Narendra Siddaiah, Gabriel Chee En Ngui, Thomas Hawthorne, Katie Wilson, Kirstie Wright, Nuruljannah Ismail, Tochukwu Bede Oluh, Murray Williams, Ashli Antoine, Peter M Odor, Naomi Jordan, Sarah Elgarf, Gruffudd Thomas, Catherine Britton‐Jones, Bejal Patel, Shona Sandhu, Ben Wooldridge, Saarah Rana, Zi Chao Soo, Amitesh Chugh, Danboy Ayodeji, Andrew Tang, James P King, Diana Neely, Nithin Jayan, Najade Sheriff, Anna Williams, Beatrice Meilak, Joe Woodcock, Morwenna Coultate, Venkat Sundaram, Matthew Sinnott, Mayur Murali, Shriya Kumar, Joanna Wong, Farzana Husain, Muska Miller, Elizabeth Brown, Jan Man Wong, Kim Rhodes, Lucy Liu, Daveena Meeks, Ben Milne, Jenny Olsson, Mitul Patel, Shilen Shah +330 morewiley +1 more sourceNine years' experience of trial of labor after two previous cesarean sections at a tertiary hospital – A retrospective cohort study
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.A trial of labor after two previous cesarean sections (TOLAC‐2) at term with no labor induction or augmentation resulted in a 55.6% success rate for vaginal births, without an increase in maternal or neonatal morbidity and mortality. Abstract Introduction
The global cesarean section (CS) rate has increased to 21.1% between 1990 and 2018.Kelvin Z. X. Lee, Binny Priya Sesurajan, Harshaana Ramlal, Tak Yein Lim, Mahesh Choolani, Vanaja Kalaichelvan, Lin Lin Su, Ida Ismail‐Pratt, Citra N. Z. Mattar, Sarah W. L. Li +9 morewiley +1 more sourceCGM‐derived average glucose is more strongly associated with microvascular complications than HbA1c in type 1 diabetes
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims
To compare the associations of HbA1c and continuous glucose monitoring (CGM)‐derived average glucose with microvascular complications in adults with type 1 diabetes, and to assess the clinical utility and stability of metrics capturing glycation discordance. Materials and methods
Observational assessment of 9023 paired measurements of CGM Roland H. Stimson, Michael S. Crane, Anna R. Dover, Shareen Forbes, Rohana J. Wright, Marcus J. Lyall, Mark W. J. Strachan, Fraser W. Gibb +7 morewiley +1 more sourceMicrobiome‐Based Modeling of CAR‐T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing
European Journal of Haematology, EarlyView.ABSTRACT
The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell‐driven cancer immunotherapies. However, clinical studies supporting microbiota‐based interventions in chimeric antigen receptor T‐cell (CAR‐T) therapy remain scarce.Rafael Hernani, Eliseo Albert, Carlos Hernani‐Morales, Sheila Zúñiga, Ana Benzaquén, Laura González‐Castillo, Ester Colomer, Júlia Morell, José Francisco Català‐Senent, José Luis Piñana, Estela Giménez, Ariadna Pérez, Juan Carlos Hernández‐Boluda, Ignacio Arroyo, Marcos Rivada, Teresa Barber, Teresa Alemany, Enric Santacatalina, Pilar Rentero‐Garrido, María José Terol, Rafael Díaz, David Navarro, Carlos Solano +22 morewiley +1 more sourceNanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy
Epilepsia, EarlyView.Abstract Objective
Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...Samantha L. Reed, Lauren M. Aiani, Eesha Faiz, Emmanuel Adediran, Morris Benveniste, Kevin S. Murnane, Martin D'Souza, Andrew Escayg, Jennifer C. Wong +8 morewiley +1 more sourceNewly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators
The FEBS Journal, EarlyView.Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz +13 morewiley +1 more sourceZebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog
The FEBS Journal, EarlyView.Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.Maria Rosaria Coppola, Deianira Bellitto, Erfan Asgari, Virginia Bazzurro, Giorgia Casucci, Francesco Piacente, Matteo Bozzo, Davide Ceresa, Costantino Parisi, Cecilia Winata, Simona Candiani, Michela Tonetti +11 morewiley +1 more sourceLigand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures
The FEBS Journal, EarlyView.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet +7 morewiley +1 more source
