Results 61 to 70 of about 12,658 (224)

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma. [PDF]

, 2015
横紋筋肉腫におけるゲノム・エピゲノム異常の全体図を解明 -横紋筋肉腫を4群に分類-. 京都大学プレスリリース. 2015-07-03.Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome ...
Aburatani, Hiroyuki, Akiyama, Masaharu, Chiba, Kenichi, Hanada, Ryoji, Hayashi, Yasuhide, Hoshino, Noriko, Hosoi, Hajime, Igarashi, Takashi, Kato, Keisuke, Kato, Motohiro, Koh, Katsuyoshi, Miyachi, Mitsuru, Miyano, Satoru, Nagae, Genta, Nishimura, Riki, Nomura, Yuko, Ogawa, Seishi, Oka, Akira, Okita, Hajime, Okuno, Yusuke, Sato, Yusuke, Seki, Masafumi, Shimamura, Teppei, Shiozawa, Yusuke, Shiraishi, Yuichi, Souzaki, Ryota, Taguchi, Tomoaki, Takita, Junko, Tanaka, Hiroko, Tanaka, Yukichi, Yoshida, Kenichi   +30 more
core   +1 more source

A RARE CASE REPORT OF PARATESTICULAR RHABDOMYOSARCOMA IN AN ADULT PATIENT

Pakistan Armed Forces Medical Journal, 2021
Rhabdomyosarcoma is a malignancy of mesenchymal tissue origin typically occurring in childhood and adolescence, with an incidence rate of of 4.3 patients per million population per anum. Primary rhabdomyosarcoma of para-testicular origin is an infrequent
Mussadique Ali, Chandumal ., Manzoor Khan, Jhanzeb Iftikhar, Samia Yasmeen, Umm e Kalsoom Awan   +5 more
doaj   +1 more source

Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma. [PDF]

, 2017
Purpose: Pazopanib, a multireceptor tyrosine kinase inhibitor targeting primarily VEGFRs1–3, is approved for advanced soft tissue sarcoma (STS) and renal cell cancer. Downstream of VEGFR, trametinib is an FDA-approved MEK inhibitor used for melanoma.
Azad, Nilofe A., Kurzrock, Razelle, Ludwig, Joseph A., Meric-Bernstam, Funda, Meyer, Christian, O\u27Connor, Ashley, Roszik, Jason, Shaw, Kenna, Subbiah, Vivek, Zahurak, Marianna L., Zinner, Ralph G.   +10 more
core   +1 more source

MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors. [PDF]

, 2016
© Springer Science+Business Media New York 2015Among noncoding RNAs, microRNAs (miRNAs) have been most extensively studied, and their biology has repeatedly been proven critical for central nervous system pathological conditions.
A Ranger, A Spalice, A Tessitore, B Zhang, C Wang, DK Birks, DN Louis, E Ferretti, E. Kanavakis, F Chassoux, F Ozlen, F Wang, G Cui, G Della Vittoria Scarpati, G. I. Lambrou, I Qaddoumi, J Cai, J Qiao, K Yao, K. Stefanaki, M Braoudaki, M Braoudaki, M Li, M Maschio, M Thom, M Wang, M. Braoudaki, N. Prodromou, P Zhou, R Kunder, S Lu, S Vella, S. A. Papadodima, SB Ng, TM Brinkman, X Zhang, Z Jamali   +36 more
core   +2 more sources

Embryonal rhabdomyosarcoma of the biliary tree: A rare cause of obstructive jaundice in children which can mimic choledochal cysts

Indian Journal of Radiology and Imaging, 2017
Jaundice in children is more often due to hepatic disease than obstruction. Differential considerations for obstructive jaundice in children include choledocholithiasis, choledochal cysts and rare neoplasms.
Dhara J Kinariwala, Andrew Y Wang, Patrick D Melmer, William P McCullough   +3 more
doaj   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Laryngeal Embryonal Rhabdomyosarcoma: A rare adult neoplasm

Ear, Nose & Throat Journal
The embryonal subtype of rhabdomyosarcoma is the most frequent, commonly seen in children. However, it is uncommon to discover this subtype in adults, especially in the larynx.
Farah Hafiz Yusuf MBBS, FCPS, Irfan Shaikh MBBS, FCPS, Muntazir Hussain MBBS, FCPS, Aabiya Arif MBBS, Danish Rahim MBBS FCPS, Atif Hafeez Siddiqui MBBS, FCPS, MCPS, DLO, Shuja Farrukh MBBS, FCPS, Sameer Saleem Tebha MBBS, Zil e Huma MBBS   +8 more
doaj   +1 more source

A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors

Acta Paediatrica, EarlyView.
ABSTRACT Aims Paediatric cancer survivors often experience treatment‐induced immunosuppression, requiring post‐treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute‐lymphoblastic‐leukaemia (ALL), may not be applicable across all ...
Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J. Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein   +17 more
wiley   +1 more source

Relationship Between PTBP1 and Pancreatic Cancer Based on microRNA and Behavior During TYMS‐Mediated Carcinogenesis

Cancer Science, EarlyView.
Corresponding Author and colleagues identify a pancreas‐enriched microRNA, miR‐216b‐5p, that suppresses PTBP1 and its downstream effector TYMS. Their findings reveal a novel miR‐216b‐5p/PTBP1/TYMS regulatory axis driving pancreatic cancer progression and establish PTBP1 as a central molecular regulator of tumor biology beyond its metabolic role ...
Shigenori Suzuki, Hiroaki Hase, Yosuke Inomata, Jun Arima, Kentaro Jingushi, Atsushi Tomioka, Nao Kawaguchi, Hiroki Hamamoto, Ryo Tanaka, Yoshiro Imai, Mitsuhiro Asakuma, Tomohito Tanaka, Kazutake Tsujikawa, Kohei Taniguchi, Sang‐Woong Lee   +14 more
wiley   +1 more source

Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition [PDF]

, 2015
BACKGROUND: Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma Kinase (ALK) and MET gene has been implicated in the malignant progression of RMS ...
CAMERO, SIMONA, CECCARELLI, SIMONA, CLERICO, Anna, DOMINICI, Carlo, Losty, Paul D, Mannarino, Olga, Mcdowell, Heather P, MEGIORNI, Francesca, PAIANO, MILENA, Pizer, Barry, PIZZUTI, Antonio, Shukla, Rajeev   +11 more
core   +1 more source