Results 111 to 120 of about 14,550 (256)

Within‐tree spatial heterogeneity of sap flow velocities and wood properties and its effect on the uncertainty of tree level sap flux estimates

PLANTS, PEOPLE, PLANET, EarlyView.
As forests are important for biodiversity and recreation and provide vital resources globally, it is essential that their health can be accurately monitored, for example, by using sap flow probes to measure tree water uptake. We investigated whether sap flow measurements might differ at various locations within the same tree due to variation in wood ...
Stefan Seeger, Markus Weiler, Martin Maier   +2 more
wiley   +1 more source

Comprehensive Review on the Toxicity of Five Main AQ Constituents from Rhubarb: Mechanisms, Challenges and Future Perspectives. [PDF]

Drug Des Devel Ther
Yu L, Jiang Y, Li P, Wang J, Tang P, Zhao Y.   +5 more
europepmc   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Subcutaneous nodules on the elbows of a teenager. [PDF]

JAAD Case Rep
Haveric A, Rhein JG, Lee JB, Waseh S, Hsu S, Metkowski AR.   +5 more
europepmc   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Rhein attenuates severe acute pancreatitis-associated intestinal injury through PPARγ regulating macrophage activation. [PDF]

Chin Med J (Engl)
Lu H, Shen H, Cui J, Yang J.
europepmc   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Berberine-Mediated BCRP Inhibition Enhances Systemic Exposure of Rhein: A Study to Unravel the Pharmacokinetic Basis of Synergy in Da-Huang-Xiao-Shi Decoction. [PDF]

Pharmaceuticals (Basel)
Xu Z, Li H, Xue H, Wang X, Wang T, Zhou Y, Gu J, Shi R.   +7 more
europepmc   +1 more source

The Fargo‐Moorhead Diversion: Flood Protection or Sprawl Promotion?

River Research and Applications, EarlyView.
ABSTRACT Urban growth and development opportunities are needed worldwide, but growth and development must be hazard‐aware and should follow smart‐growth principles. The $2.89 billion Fargo‐Moorhead Area Diversion Project was designed to provide flood protection following damaging floods on the Red River of the North.
Nicholas Pinter, Ryan G. Miller, Joel Paulsen   +2 more
wiley   +1 more source

Evaluating the Role of Social Capital for the Design of Sustainable River Governance Strategies: The Case of Tagus River

Sustainable Development, EarlyView.
ABSTRACT This study examines the role of social capital in designing and implementing more effective governance strategies to improve the state of the Tagus River's significantly deteriorated middle reach (Spain). We employed social network analysis (SNA) to evaluate the bonding, bridging and linking social capital and the quality of stakeholder ...
Leticia Blázquez, Juan A. García, José M. Bodoque   +2 more
wiley   +1 more source