Results 111 to 120 of about 76,583 (247)

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays

Epilepsia, EarlyView.
Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku, Lena Gschossmann, Kerstin Hallmann, Heinz Beck, Kunihiko Araki   +4 more
wiley   +1 more source

In Vitro and In Vivo Toxicity and Antiviral Activity of Rhein Derivatives Against Nervous Necrosis Virus

Aquaculture, Fish and Fisheries
Rhein has been demonstrated to exhibit antiviral activity against nervous necrosis virus (NNV). As rhein coexists in plants with various structurally analogous natural derivatives and may acquire improved biochemical properties through chemical ...
Zhiqing Tian, Shuifang Zhu, Jialong Hu, Yaguang Zhu, Fan Jiang, Haolong Cong   +5 more
doaj   +1 more source

Cross‐material memory prediction: Influence of preoperative visual memory on postoperative verbal memory change after left anterior temporal lobe resection in people with epilepsy

Epilepsia, EarlyView.
Abstract Objective Left anterior temporal lobe resection (TLR) in people with epilepsy is associated with a high risk of postoperative verbal memory decline. Whereas substantial evidence supports the role of preoperative verbal memory in predicting postoperative verbal memory change, the potential contribution of preoperative visual memory has been ...
Lea Marie Reisch, Anne Hagemann, Johanna Lena Hopf, Florian J. Muecke, Friedrich G. Woermann, Christian G. Bien, Philip Grewe   +6 more
wiley   +1 more source

Entwicklungskonzept Innenstadt Ludwigshafen am Rhein [PDF]

, 2006
ENTWICKLUNGSKONZEPT INNENSTADT LUDWIGSHAFEN AM RHEIN Entwicklungskonzept Innenstadt Ludwigshafen am Rhein / Jacob, Andreas [Bearb.] (Rights reserved) (-
Jacob, Andreas [Bearb.]
core  

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Epilepsia, EarlyView.
Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS. Methods We identified participants with highest (n = 59) versus lowest (n 
Sophie von Brauchitsch, Nils Hartung, Robin A. Karge, Bobby Koeleman, Samuel F. Berkovic, Danielle M. Andrade, Francesca Bisulli, Antonio Gambardella, Renzo Guerrini, Ingrid E. Scheffer, Ingo Helbig, Wolfram S. Kunz, Holger Lerche, Hiltrud Muhle, Christian Boßelmann, Savvas S. Papacostas, Mark I. Rees, Sanjay M. Sisodiya, Pasquale Striano, Lynnette Sadleir, Yvonne Weber, Dennis Lal, Costin Leu, Philipp S. Reif, Stefan Wolking, Felix Rosenow, Karl Martin Klein, for the Epi25 Collaborative   +27 more
wiley   +1 more source

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis evaluating the efficacy and safety of fenfluramine in patients with Dravet syndrome stratified by age, number of previously attempted antiseizure medications, and SCN1A pathogenic variant status using data pooled from the three pivotal randomized controlled trials ...
Rima Nabbout, Joseph Sullivan, Stéphane Auvin, J. Helen Cross, Orrin Devinsky, Antonio Gil‐Nagel, Renzo Guerrini, Kelly G. Knupp, M. Scott Perry, Rocío Sánchez‐Carpintero, An‐Sofie Schoonjans, Ingrid E. Scheffer, Nicola Specchio, Adam Strzelczyk, James Wheless, Elaine C. Wirrell, Diego Morita, Patrick Healy, Mélanie Langlois, Amélie Lothe, Lieven Lagae   +20 more
wiley   +1 more source

Zn2+-triggered mineralized hydrogel for enhanced deep burn wound healing

Nano Research
The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields. Here, we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate (HA), Rhein, and Zn2+ (denoted ...
Yuqian Ji, Yongchang Tian, Yu Yan, Yunfeng Li, Xiaonong Zhang, Gao Li, Chunsheng Xiao   +6 more
doaj   +1 more source

Vehicle Fires: Significant Fire Hazard in Transportation Infrastructure

Fire and Materials, EarlyView.
ABSTRACT Vehicle flammability poses a critical threat to transportation infrastructure, with recent fires in depots, tunnels, and car parks highlighting systemic vulnerabilities. These incidents often result in the total loss of vehicles and buildings, revealing the inadequacy of current fire safety standards for vehicle materials.
Anja Hofmann‐Böllinghaus, Andrea Klippel, Kira Piechnik   +2 more
wiley   +1 more source

Encountering anthropologists through body‐mapping: On risk‐taking, experimentation and solidarity in the neoliberal university

Feminist Anthropology, EarlyView.
Abstract This article turns a workshop session and the university as a locus of knowledge production into objects of ethnographic investigation. The authors reflect on our experience co‐facilitating a body‐mapping session with a group of anthropologists of different backgrounds, ages and career stages—all women—from universities across Europe, during a
Koreen M. Reece, Magdalena Suerbaum
wiley   +1 more source