An Integrative Computational Pipeline for CK2 Inhibitor Discovery in Triple-Negative Breast Cancer Using Virtual Screening, Molecular Dynamics, Machine Learning, and Density Functional Theory. [PDF]
Khan A +6 more
europepmc +1 more source
Broke and Broken: The Crises Facing Local Government in England
Abstract English local government faces a perilous position owing to insufficient funding, structural issues and capacity challenges. Fourteen years of austerity have significantly reduced council budgets, while increased demand for services—particularly adult social care—has strained resources.
David Jeffery
wiley +1 more source
Abstract Participants in Russia's 1825 Decembrist uprising against the Tsarist regime were, quite literally, a case study in French cultural influence upon Russia. This is particularly true as it relates to Russia's emotional cultures. Although this has not, traditionally, been the primary focus of historical analysis of this event (in Soviet or ...
ADAM COKER
wiley +1 more source
A Comparison of the Performance of Horses from the International WBFSH Rankings in Dressage, Jumping and Eventing Based on Their Sex, Age, Proportion of Thoroughbred Genes and Affiliation to the Studbook. [PDF]
Sobotková E +3 more
europepmc +1 more source
Dutch dilemma: Housing prices and flood risk exposure
Abstract This article studies the impact of flood risk exposure on housing prices in a major river delta. Analyzing 1.8 million property transactions from 1998 to 2023 in the Netherlands, we find an average price discount of 1.1%. We observe considerable heterogeneity in price effects driven by exposure intensity, institutional settings that vary ...
Piet Eichholtz +2 more
wiley +1 more source
Self-assembled nanoparticles from Xiexin Decoction attenuate ulcerative colitis by targeting VDAC1-Mediated NLRP3 inflammasome activation. [PDF]
Chu Z +15 more
europepmc +1 more source
Abstract Existing literature posits that attitudes toward immigration are shaped by the impact of migrants on native workers' wages and employment, as well as by various other material, cultural, and social concerns. However, empirically disentangling these influences can be challenging.
Lena Maria Schaffer, Gabriele Spilker
wiley +1 more source
ABSTRACT Background IgE‐mediated food allergy burdens individuals, families and healthcare systems. Randomised controlled trials indicate early introduction and regular consumption of common food allergens in infancy can reduce food allergy risk. Few studies have explored parental and healthcare professional experiences. This systematic review examines
Karen Wright +14 more
wiley +1 more source
Mechanistic insights into the anti-neuroinflammatory effects of cassia <i>obtusifolia</i> in Parkinson's disease: a network pharmacology-based study. [PDF]
Lian X +5 more
europepmc +1 more source
This is the first randomised placebo‐controlled trial of intralymphatic immunotherapy using a microcrystalline tyrosine‐adjuvanted grass pollen allergoid. Three ultrasound‐guided ILIT injections were well tolerated and reduced combined symptom‐medication scores compared with placebo. The findings support further optimisation and clinical development of
Lara Šošić +13 more
wiley +1 more source

