Results 71 to 80 of about 125,675 (280)

Liganden der Lipidtasche induzieren allosterische Modulation der Proteindynamik im Bereich des aktiven Zentrums der Proteinkinase p38α

Angewandte Chemie, EarlyView.
Bei der Suche nach neuen allosterischen Stellen in der Serin/Threonin‐Kinase p38α deckt die NMR‐Spektroskopie eine dynamische Kopplung zwischen dem katalytischen Zentrum und der Lipidtasche auf. Die Ergebnisse offenbaren bewegungsbezogene Interdependenzen, die entfernte Regionen des Enzyms miteinander verbinden, was die Lipidtasche als ...
Sara Medina Gómez, Laurin T. Homberg, Mike Bührmann, Daniel Rauh, Rasmus Linser   +4 more
wiley   +1 more source

Rhein shows potent efficacy against non-small-cell lung cancer through inhibiting the STAT3 pathway

Cancer Management and Research, 2019
Lehe Yang,1–3,* Jifa Li,1,* Lingyuan Xu,1–3,* Shichong Lin,1–3 Youqun Xiang,3 Xuanxuan Dai,3 Guang Liang,2 Xiaoying Huang,3 Jiandong Zhu,1 Chengguang Zhao1,2 1Department of Respiratory Medicine, Affiliated Yueqing Hospital, Wenzhou ...
Yang L, Li J, Xu L, Lin S, Xiang Y, Dai X, Liang G, Huang XY, Zhu J, Zhao C   +9 more
doaj  

Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling

PPAR Research, 2012
Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine. However, the components of Rheum palmatum that play the antiobesity role are still uncertain.
Yu Zhang, Shengjie Fan, Na Hu, Ming Gu, Chunxiao Chu, Yiming Li, Xiong Lu, Cheng Huang   +7 more
doaj   +1 more source

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α

Angewandte Chemie International Edition, EarlyView.
Used in search of novel allosteric sites in the serine/threonine kinase p38α, NMR spectroscopy reveals a dynamic coupling between the catalytic and lipid pockets. The findings uncover a motional interdependence that links distant regions of the enzyme, highlighting the lipid pocket as a promising site for allosteric intervention.
Sara Medina Gómez, Laurin T. Homberg, Mike Bührmann, Daniel Rauh, Rasmus Linser   +4 more
wiley   +1 more source

Theatre information : searched and recorded once, manifold extended and used [PDF]

, 2006
Düsseldorf is the capital of North Rhine-Westphalia, the state with the highest number of inhabitants in Germany. The city has a rich cultural history: The theatre history started in 1585 (the festivities in the context of a princely marriage at ...
Schild, Margret
core  

New techniques for old bones: Morphometric and diffeomorphometric analysis of the bony labyrinth of the Reilingen and Ehringsdorf Neandertals

The Anatomical Record, EarlyView.
Abstract Neandertals are known to possess very distinctive traits in their bony labyrinth morphology, such as an inferiorly positioned posterior canal and a very low number of turns in the cochlea. Hence, the inner ear has been often used to assess the Neandertal status of fragmentary fossils.
Alessandro Urciuoli, Julia Diez‐Valero, Ignacio Martínez, Rolf Quam, Brian A. Keeling, Nicole M. Webb, Mercedes Conde‐Valverde   +6 more
wiley   +1 more source

‘Fish in simulated water’? A Bourdieusian analysis of Chinese doctoral students' learning experiences in Southeast Asian developing countries

British Educational Research Journal, EarlyView.
Abstract International student mobility (ISM) has historically followed a pattern of movement from developing regions to developed countries. However, in recent years, there has been a noticeable increase in the number of Chinese students pursuing doctoral studies in Southeast Asian developing countries, an area that has received relatively little ...
Yueyang Zheng, Kun Dai, Alan C. K. Cheung   +2 more
wiley   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

Drug Design, Development and Therapy, 2017
Hui Ge,1,* Hao Tang,2,* Yanbing Liang,2 Jingguo Wu,2 Qing Yang,2 Lijin Zeng,2 Zhongfu Ma2 1Department of Health Care Clinic, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2Department of General Internal Medicine, the First ...
Ge H, Tang H, Liang Y, Wu J, Yang Q, Zeng L, Ma Z   +6 more
doaj  

Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway

Open Medicine
Rhein is a natural anthraquinone substance extracted from Rheum palmatum L. This study aimed to evaluate Rhein’s protective effects against skin wound by in vivo and in vitro models and investigate whether its protective mechanism regulated the PI3K/AKT ...
Yang Dong, Li Wei, Xiang Ping, Ge Tingrui, Li Huazhuan, Zhang Yonggang   +5 more
doaj   +1 more source