Results 111 to 120 of about 103,300 (196)

Decidua macrophages display a restrained inflammatory profile during chorioamnionitis. [PDF]

Front Immunol
Pithia N, Musumarra CV, Protti G, Del Vecchio G, Hsu FM, Ma F, Cappelletti M, Tilburgs T, Prasanphanich NS, Miller LA, Morselli M, Pellegrini M, Jobe AH, Chougnet CA, Presicce P, Kallapur SG.   +15 more
europepmc   +1 more source

Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Qiaowei Zhang, Shuwen Xue, Zhi Gao, Panlai Shi, Li Wang, Qi Feng, Xiangdong Kong, Xiaofan Zhu   +7 more
wiley   +1 more source

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source

A hierarchical framework for cortical and subcortical gray-matter parcellation across rodents, primates, and humans. [PDF]

Nat Commun
Venkadesh S, Tian Y, Linn WJ, Barrios-Martinez J, Mansour H, Cook J, Schaeffer DJ, Szczupak D, Silva AC, Johnson GA, Yeh FC.   +10 more
europepmc   +1 more source

An Open‐Label Study Investigating the 5‐HT2A Receptor Occupancy of Remlifanserin (ACP‐204) With the PET Radioligand [18F]Altanserin in Healthy Male Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 9, September 2026.
Abstract Remlifanserin (ACP‐204) is a selective 5‐HT2A receptor inverse agonist that builds upon scientific findings of its structural analog, pimavanserin. This Phase 1, open‐label study in healthy adults (N = 16) describes the central 5‐HT2A receptor occupancy of remlifanserin at different doses and plasma concentrations using positron emission ...
Ethan S. Burstein, Christine Sandiego, Brian Raether, Xiaoshu Feng, Bryan Dirks, Mona Darwish, Peter Zhang, David S. Russell, Eugenii A. Rabiner, Sanjeev Pathak   +9 more
wiley   +1 more source

Comprehensive genomic characterization of herpes B virus isolated from a wild long-tailed macaque reveals conserved entry mechanisms and zoonotic potential. [PDF]

Emerg Microbes Infect
Paungpin W, Chaiwattanarungruengpaisan S, Thongdee M, Sariya L, Sapkanarak K, Kemthong T, Dangsagul W, Suwanpakdee S, Wiriyarat W, Malaivijitnond S.   +9 more
europepmc   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS-CoV-2 Infection. [PDF]

MedComm (2020)
Wang Q, Zhou Y, Ding T, Sun Y, Yang Y, Wu Y, Liu J, Lu S, Yang J.   +8 more
europepmc   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

Correction: Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir. [PDF]

PLoS Pathog
PLOS Pathogens Staff.
europepmc   +1 more source

Mitigating Effects of Nest Structure on Predation Risk in Hainan Partridge (Arborophila ardens)

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Enclosed nest structures can disrupt predator search efficiency and reduce predation risk. Predation rate in the uncovered group was significantly higher than that in the covered group. Our study highlights the functional limitations of nest‐structure evolution within complex predation environments.
Yuhan Zhang, Yishuo Ding, Jing Wang, Qingling Zeng, Yuxin Xu, Wei Liang, Xiaodong Rao   +6 more
wiley   +1 more source