Results 111 to 120 of about 158,952 (268)

Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques

Cell, 2016
Summary Optogenetic studies in mice have revealed new relationships between well-defined neurons and brain functions. However, there are currently no means to achieve the same cell-type specificity in monkeys, which possess an expanded behavioral ...
William R. Stauffer, Armin Lak, A. Yang, Mélodie Borel, O. Paulsen, E. Boyden, W. Schultz   +6 more
semanticscholar   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Nature, 2021
Annette B. Vogel, I. Kanevsky, Y. Che, K. Swanson, A. Muik, M. Vormehr, L. Kranz, Kerstin C. Walzer, Stephanie Hein, Alptekin Güler, Jakob Loschko, M. Maddur, Ayuko Ota-Setlik, Kristin Tompkins, J. Cole, B. G. Lui, Thomas Ziegenhals, Arianne Plaschke, D. Eisel, Sarah C. Dany, Stephanie Fesser, Stephanie Erbar, F. Bates, D. Schneider, B. Jesionek, Bianca Sänger, A. Wallisch, Yvonne Feuchter, H. Junginger, S. A. Krumm, André P. Heinen, P. Adams-Quack, J. Schlereth, Stefan A Schille, Christoph Kröner, Ramón de la Caridad Güimil Garcia, T. Hiller, Leyla Fischer, R. Sellers, S. Choudhary, O. Gonzalez, F. Vascotto, Matthew R. Gutman, J. Fontenot, Shannan Hall-Ursone, K. Brasky, M. Griffor, Seungil Han, A. Su, J. Lees, Nicole L. Nedoma, E. Mashalidis, P. Sahasrabudhe, Charles Y. Tan, D. Pavliakova, Guy Singh, Camila R. Fontes-Garfias, M. Pride, Ingrid L Scully, Tara Ciolino, Jennifer Obregon, M. Gazi, R. Carrion, Kendra J Alfson, W. Kalina, D. Kaushal, P. Shi, T. Klamp, Corinna Rosenbaum, A. Kuhn, Ö. Türeci, P. Dormitzer, K. Jansen, U. Şahin   +73 more
semanticscholar   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Face pareidolia in the rhesus monkey

Current Biology, 2017
SUMMARY Face perception in humans and non-human primates is rapid and accurate[1–4]. In the human brain, a network of visual processing regions is specialized for faces[5–7].
J. Taubert, S. Wardle, Molly Flessert, D. Leopold, Leslie G. Ungerleider   +4 more
semanticscholar   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets

Journal of Anatomy, EarlyView.
We introduce the MacBrain Resource Center (MBRC) Collections of rhesus macaque embryonic brain tissue. Here, we illustrate histo‐ and immunohistology from our dynamically growing Collection 6, which currently contains >10,000 zoomable and downloadable images from n = 14 male and female embryos from early to late in gestation.
Valeria Mendoza‐Silva, Emma Burke, Lucy Greene, Mikhail Rodov, Janja Kopić, Phil Barello, Yury M. Morozov, Keiko Moriya‐Ito, Chiaki Ohtaka‐Maruyama, Zeljka Krsnik, Pasko Rakic, Alvaro Duque   +11 more
wiley   +1 more source

Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies

Frontiers in Immunology, 2017
The rhesus macaque is a critically important animal model in biomedical research, most recently playing a key role in the development of vaccines against human immunodeficiency virus-1.
A. Ramesh, S. Darko, A. Hua, Glenn Overman, Amy Ransier, J. Francica, Ashley Trama, G. Tomaras, B. Haynes, D. Douek, T. Kepler   +10 more
semanticscholar   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques

PLoS ONE, 2017
Animal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic.
Lark L. Coffey, P. Pesavento, R. Keesler, Anil Singapuri, Jennifer K Watanabe, R. Watanabe, J. Yee, E. Bliss-Moreau, E. Bliss-Moreau, Christina Cruzen, Kari L. Christe, J. Reader, Wilhelm von Morgenland, Anne M. Gibbons, A. Allen, J. Linnen, Kui Gao, E. Delwart, G. Simmons, M. Stone, Marion C Lanteri, S. Bakkour, M. Busch, J. Morrison, K. V. Rompay   +24 more
semanticscholar   +1 more source

Pharmacokinetics of a Single Subcutaneous Extended‐Release Buprenorphine (Ethiqa XR) in Healthy Beagles

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study evaluated the pharmacokinetics of an extended‐release buprenorphine formulation (Ethiqa XR) in dogs and explored potential sex differences. Twelve healthy intact beagles (6 males and 6 females) received a single subcutaneous injection of Ethiqa XR (0.2 mg/kg).
Kornelia Tiffinger, Hiroko Enomoto, Ronald E. Baynes, Laura M. Neumann, B. Duncan X. Lascelles, Masataka Enomoto   +5 more
wiley   +1 more source