Results 111 to 120 of about 213,696 (264)

Pharmacokinetics of 2 mg/kg Bupivacaine in a Rectus Abdominis Sheath Block in Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Administering large volumes of bupivacaine in the rectus abdominis sheath (RAS) block in horses could cause local anesthetic toxicity. This study aimed to evaluate the pharmacokinetics of 2 mg/kg bupivacaine in RAS blocks and the associated toxicity risk.
Daniel M. Sakai, Yushun Ishikawa, Jessica S. Y. Im, Shufan Zhang, Rachel A. Reed, Jane E. Quandt, Michele Barletta, Heather K. Knych   +7 more
wiley   +1 more source

AI Alignment Versus AI Ethical Treatment: 10 Challenges

Analytic Philosophy, EarlyView.
ABSTRACT A morally acceptable course of AI development should avoid two dangers: creating unaligned AI systems that pose a threat to humanity and mistreating AI systems that merit moral consideration in their own right. This paper argues these two dangers interact and that if we create AI systems that merit moral consideration, simultaneously avoiding ...
Adam Bradley, Bradford Saad
wiley   +1 more source

Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques. [PDF]

, 2019
Herpes simplex virus 2 (HSV-2) is a common sexually transmitted infection with a highly variable clinical course. Many infections quickly become subclinical, with episodes of spontaneous virus reactivation.
Burgener, Adam, Carroll, Timothy, Corey, Lawrence, Farr Zuend, Christina, Fritts, Linda, Hansen, Scott G, Huang, Meei-Li, Huang, Ying, Koelle, David M, Lo, Ming, Ma, Zhong-Min, Miller, Christopher J, Nöel-Romas, Laura, Picker, Louis J, Sun, Sijie, Zhu, Jia   +15 more
core  

Periodontal considerations during orthodontic intrusion and extrusion in healthy and reduced periodontium

Periodontology 2000, EarlyView.
Abstract In patients with advanced periodontal disease, pathological tooth migration may occur, which may require subsequent orthodontic treatment for both aesthetic and functional purposes. When planning orthodontic treatment mechanics, intrusive or extrusive forces are frequently indicated.
Gregory S. Antonarakis, Alkisti Zekeridou, Stavros Kiliaridis, Catherine Giannopoulou   +3 more
wiley   +1 more source

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. [PDF]

, 2018
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few ...
Aagaard, Kjersti M, Adams Waldorf, Kristina M, Ardeshir, Amir, Bliss-Moreau, Eliza, Bohm, Rudolf P, Capuano, Saverio V, Chiu, Charles Y, Coffey, Lark L, Colgin, Lois M, Dudley, Dawn M, Friedrich, Thomas C, Gale, Michael, Gilbert, Margaret H, Golos, Thaddeus G, Grigsby, Peta L, Hirsch, Alec J, Hodge, Travis, Hotchkiss, Charlotte E, Keesler, Rebekah I, MacAllister, Rhonda P, Maness, Nicholas J, Martín, Claudia Sánchez-San, Mejia, Andres, Mohr, Emma L, O'Connor, David H, Panganiban, Antonito T, Patterson, Jean L, Pecoraro, Heidi L, Rajagopal, Lakshmi, Seferovic, Maxim, Simmons, Heather A, Steinbach, Rosemary J, Streblow, Daniel N, Tamhankar, Manasi, Tardif, Suzette, Van Rompay, Koen K, Veazey, Ronald S, Wang, Xiaolei   +37 more
core  

Rhesus blood group haplotype determination by nanopore sequencing and adaptive sampling enables the precise determination of complex allele combinations that could not be accurately determined by standard methods

Transfusion, EarlyView.
Abstract Background Patients with chronic transfusion needs such as those with sickle cell disease face a high risk of developing antibodies against high‐prevalence antigens in the RH blood group system, complicating transfusion therapy and potentially necessitating stem cell transplantation.
Rebekka Waldmann, Marita Führer, Annika Vogt, Dominik Nolde, Melanie Riecker, Lennart Finn Herrlich, Timo Dinse, Hubert Schrezenmeier, Christof Weinstock, David Alexander Christian Messerer   +9 more
wiley   +1 more source

MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-ASSOCIATED VACCINE PROTECTION FROM SIMIAN IMMUNODEFICIENCY VIRUS-INFECTED PERIPHERAL-BLOOD CELLS [PDF]

, 1994
Boes, J, Bontrop, RE, Cranage, M, de Vries, P, Dings, M, Dubbes, R, Heeney, JL, Jonker, M, Koornstra, W, Niphuis, H, Norley, S, Osterhaus, A, Otting, N, ten Haaft, P, van Els, C   +14 more
core   +1 more source

Bilateral simultaneous cataract surgery and intraocular lens implantation in an adult female chimpanzee (Pan troglodytes) inducing monovision

Veterinary Ophthalmology, Volume 28, Issue 2, Page 457-464, March 2025.
Abstract Background Cataract is the major cause of visual impairment in humans. Phacoemulsification with intraocular lens (IOL) implantation is the standard technique for cataract treatment with a high success rate. In a few cases, the surgical cataract procedure and lens implantation have been applied in non‐human primates.
F. Notting, Y. Cheng, M. Marinkovic, H. van Bolhuis, I. Notting   +4 more
wiley   +1 more source

Molecular characterization of D variants in Brazilian blood donors and their association with RhCE and Duffy phenotypes

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Serological classification of RhD‐negative and weak D is often insufficient in admixed populations, where diverse RHD variants have clinical implications. In Brazil's highly admixed population, RhD interpretation and donor–recipient matching are particularly challenging.
Thamy C. S. Silva, Marcia R. Dezan, Sidneia Costa, Beatriz C. Girardo, Bruno R. Cruz, Karen Ziza, Dante M. Langhi, José O. Bordin, Lilian Castilho, Carla L. Dinardo   +9 more
wiley   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source