Results 131 to 140 of about 158,952 (268)

Molecular characterization of D variants in Brazilian blood donors and their association with RhCE and Duffy phenotypes

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Serological classification of RhD‐negative and weak D is often insufficient in admixed populations, where diverse RHD variants have clinical implications. In Brazil's highly admixed population, RhD interpretation and donor–recipient matching are particularly challenging.
Thamy C. S. Silva, Marcia R. Dezan, Sidneia Costa, Beatriz C. Girardo, Bruno R. Cruz, Karen Ziza, Dante M. Langhi, José O. Bordin, Lilian Castilho, Carla L. Dinardo   +9 more
wiley   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Better 10‐Year Cerebrovascular Outcome After Transplant Than on Standard‐Care in Sickle Cell Anemia: DREPAGREFFE Trial

American Journal of Hematology, Volume 101, Issue 8, Page 1799-1817, August 2026.
ABSTRACT Management of cerebral vasculopathy in sickle cell anemia (SCA) includes standard‐care, that is, chronic transfusion (CT) or hydroxyurea, and hematopoietic cell transplantation (HCT). DREPAGREFFE‐1 (December 2010/June 2013), a French multicenter trial, was the first prospective trial comparing standard‐care to match sibling donor (MSD)‐HCT in ...
Francoise Bernaudin, Suzanne Verlhac, Elisabeth Ducros‐Miralles, Cécile Arnaud, Isabelle Genty, Marie Petras, Catherine Paillard, Gonzalo De Luna, Benoit Meunier, Isabelle Thuret, Annie Kamdem, Corinne Pondarré, Giovanna Cannas, Christelle Chantalat‐Auger, Nadia Firah, Sophie Pertuisel, Laure Joseph, Florence Missud, Mariane de Montalembert, Corinne Guitton, Claire Pluchart, Valentine Brousse, Monique Elmaleh, Vincent Gajdos, Emmanuella Leveillé, Ekaterina Belozertseva, Mabel Gaba, Catherine Poirot, Virginie Barraud‐Lange, Philippe Chadebech, France Pirenne, Myriam Bernaudin, Bénédicte Neven, Pierre Frange, Marie Angoso, Karima Yakouben, Bénédicte Bruno, Nathalie Dhédin, Jean‐Hugues Dalle, Regis Peffault Delatour, Camille Jung   +40 more
wiley   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Successful Single‐Session Neural Self‐Regulation Through Neurofeedback Varies Between Features

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
We demonstrate that the ‘non‐learner’ problem is not a universal personal trait: using an intra‐subject cross‐over design, all participants successfully regulated multiple rhythms despite failing to modulate Theta. We identify distinct learning trajectories, highlighting the importance of frequency specificity in neural self‐regulation.
Syrjänen E, Silva J, Astrand E
wiley   +1 more source

Rationale and Methods of a Surveillance System for Hematopoietic Stem Cell Transplantation in Patients With Hematological Malignancies: A Qualitative Participatory Action Research Approach in Middle‐Income Countries—The Experience in Iran

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Hematopoietic Stem Cell Transplantation (HSCT) represents a cornerstone in the therapeutic management of hematological malignancies, aimed at achieving durable remission and enhancing survival. Optimal post‐transplant care, however, necessitates access to near‐real‐time, actionable clinical data.
Sima Oshnouei, Mohamad Jebraeily, Mohsen Asadi‐Lari, Babak Eshrati, Rahim Asghari, Masoumeh Nabivandrezaei, Ali Arash Anoushirvani, Aarefeh Jafarzadeh‐Kohneloo   +7 more
wiley   +1 more source

First‐in‐Human Study of a Long‐Acting GLP‐1 Receptor Agonist (TE‐8105) in Overweight or Obese Adults Without Type 2 Diabetes Mellitus

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have revolutionized weight management and are becoming essential for the treatment of obesity‐related medical conditions. This study aimed to determine the pharmacokinetics, preliminary pharmacodynamics, safety, and tolerability of a long‐acting GLP‐1 receptor agonist, TE‐8105, in overweight or
Ya‐Shan Chuang, Jon D. Wright, Mun‐Teng Wong, Kushal J Paneliya, Wei‐Shiung Yang, Hsing‐Mao Chu, Tse Wen Chang, Thomas M Polasek   +7 more
wiley   +1 more source