Results 21 to 30 of about 29,755 (146)

Development of immortalized rhesus macaque kidney cells supporting infection with a panel of viruses.

open access: yesPLoS ONE, 2023
Non-human primate (NHP)-based model systems faithfully reproduce various viral diseases including Ebola, influenza, AIDS and Zika. However, only a small number of NHP cell lines are available and generation of additional cell lines could help to refine ...
Stefanie Reiter   +4 more
doaj   +1 more source

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations

open access: yesMolecular Therapy: Methods & Clinical Development, 2020
Chimeric antigen receptor (CAR)-T cells show great promise in treating cancers and viral infections. However, most protocols developed to expand T cells require relatively long periods of time in culture, potentially leading to progression toward ...
Mary S. Pampusch   +7 more
doaj   +1 more source

Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)

open access: yesBMC Genomics, 2022
Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research.
Swati Jaiswal   +14 more
doaj   +1 more source

The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human

open access: yesBMC Genetics, 2012
Background As a model organism in biomedicine, the rhesus macaque (Macaca mulatta) is the most widely used nonhuman primate. Although a draft genome sequence was completed in 2007, there has been no systematic genome-wide comparison of genetic variation ...
Yuan Qiaoping   +12 more
doaj   +1 more source

Pooled genomic indexing of rhesus macaque [PDF]

open access: yesGenome Research, 2005
Pooled genomic indexing (PGI) is a method for mapping collections of bacterial artificial chromosome (BAC) clones between species by using a combination of clone pooling and DNA sequencing. PGI has been used to map a total of 3858 BAC clones covering ∼24% of the rhesus macaque (Macaca mulatta) genome onto 4178 homologous loci in the human genome.
Aleksandar, Milosavljevic   +12 more
openaire   +2 more sources

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche

open access: yesNature Communications, 2018
Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque
Enrique Sosa   +13 more
doaj   +1 more source

An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC90) from embryonic fibroblasts

open access: yesStem Cell Research, 2017
The rhesus macaque induced pluripotent stem cell (riPSC) line, UCLAi090-A (riPSC90), was generated from rhesus embryonic fibroblast (REF) cells called REF90.
Enrique Sosa   +6 more
doaj   +1 more source

The Subcortical Atlas of the Rhesus Macaque (SARM) for neuroimaging

open access: yesNeuroImage, 2021
Digitized neuroanatomical atlases that can be overlaid onto functional data are crucial for localizing brain structures and analyzing functional networks identified by neuroimaging techniques.
Renée Hartig   +7 more
doaj   +1 more source

Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through Multiple De Novo Genome Assemblies

open access: yesFrontiers in Immunology, 2017
The rhesus macaque is a critically important animal model in biomedical research, most recently playing a key role in the development of vaccines against human immunodeficiency virus-1.
Akshaya Ramesh   +11 more
doaj   +1 more source

Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs. [PDF]

open access: yesPLoS Genetics, 2012
Tinkering with pre-existing genes has long been known as a major way to create new genes. Recently, however, motherless protein-coding genes have been found to have emerged de novo from ancestral non-coding DNAs.
Chen Xie   +9 more
doaj   +1 more source

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