Results 81 to 90 of about 29,586 (180)

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis? [PDF]

, 2017
Individualising biologic disease-modifying anti-rheumatic drugs (bDMARDs) to maximise outcomes and deliver safe and cost-effective care is a key goal in the management of rheumatoid arthritis (RA).
A Ferreiro-Iglesias, A Groof De, A Kavanaugh, A Montes Marquez, a N Burska, A Obry, A Pachot, A Picchianti Diamanti, A Ruyssen-Witrand, AP Treschow, AP Trouvin, B Bresnihan, B Mesko, B Möller, BVJ Cuppen, C a Wijbrandts, C Castro-Villegas, C Enevold, C Potter, C Trocmé, CM Weyand, CP Mavragani, D Plant, D Plant, D Plant, D-Y Chen, DA Pappas, DF McWilliams, DS Gibson, Edward M. Vital, EM Vital, F Breedveld, G Dennis, G Dennis Jr, G Ferraccioli, G Morozzi, GS Firestein, H Canhão, H Marotte, H-P Brezinschek, HG Raterman, HL Wright, I Acosta-Colman, I González-Alvaro, I Gutierrez-Roelens, I Ortea, I Ortea, IY Choi, J Adriaansen, J Cui, J Ducreux, J Holten van, J Holten van, J Inciarte-Mundo, J Kikuchi, J Oliver, J Pieper, J Sellam, J Sellam, J Sellam, J Sellam, J Wang, J Wang, JAB Nies van, JD Cañete, JD Isaacs, JE Gottenberg, JL Nam, João Eurico Fonseca, JT Joensuu, JW Whitaker, K Chatzidionysiou, K Hambardzumyan, K Kayakabe, K Klein, K Owczarczyk, K Shimamoto, K Uno, K Vos, KL Hyrich, KL Hyrich, L Mancarella, LE Kristensen, LG Baarsen van, LGM Baarsen Van, M Abildtrup, M Ammari, M Nakou, M Scarsi, M Scarsi, M Umemura, Maya H. Buch, MH Buch, MH Buch, MH Buch, MH Stradner, MJ Leandro, MJ Townsend, MK Crow, MK Söderlin, P Roll, PA Schouwenburg van, PP Tak, R Klaasen, R Priori, RJ Maneiro, RM Thurlings, RM Thurlings, S Alzabin, S Das, S Dass, S Fabre, S Fabre, S Iwata, S Kelly, S Kubo, S Nakamura, S Rosengren, S Saevarsdottir, S Visvanathan, S Visvanathan, S Vosslamber, S-Y Kawashiri, SB Krintel, SC Nair, SK Sieberts, SL Smith, SL Smith, SR Kapoor, TC Pouw Kraan van der, TJM Smeets, U Meusch, V Badot, Vasco C. Romão, VE Hogan, W Hueber, Y Sanayama, Y-M Pers, YH Lee, YKO Teng, Z Mahmood   +140 more
core   +3 more sources

Facilitating Expedited Drug Approval– the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, Accepted Article.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Inosine triphosphate pyrophosphatase activity as a potential predictor of methotrexate remission in juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Background Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients don't respond. Low inosine‐triphosphate‐pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated ITPA role and the underlying mechanisms in vitro.
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Health Impacts of Traditional Medicines and Bio-prospecting: A World Scenario Accentuating Bhutan's Perspective [PDF]

, 2008
Life without natural products is unimaginable. It has provided mankind with oxygen, water, fire, food, clothing, shelter and medicine. Its public health impact is considerably high, especially of traditional medicines and nature-based modern drugs.
Wangchuk, Phurpa
core  

Evaluating the Antioxidant Capacity of Rheum Ribes via Cupric Reducing Antioxidant Capacity, Ferric Reducing Antioxidant Power and 2,2-Diphenyl-1- picrylhydrazyl Methods

Pharmata
Objective: It was aimed at determining the antioxidant capacity of the above-ground parts of the Rheum ribes species, known as “Iskın,” which grows in the high parts of Erzurum province, using different methods.Methods: Methanol extracts have been ...
Esen Sezen Karaoğlan, Onur Senol, Semih Özli   +2 more
doaj   +1 more source

Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is a multi‐organ disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

ОБЗОР МНОГООБРАЗИЯ БИОЛОГИЧЕСКИХ СВОЙСТВ И СПОСОБОВ ПРИМЕНЕНИЯ РАСТИТЕЛЬНОГО СЫРЬЯ RHEUM RHAPONTICUM L.

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2020
Многочисленные способы хозяйственного применения ревеня в промышленности зависят от разнообразного биохимического состава различных частей растения.
Алла ГЛАДКАЯ, Леонид ВОЛОЩУК, Тудор НАСТАС   +2 more
doaj  

Single‐cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Bronchiolitis obliterans. [PDF]

, 1989
Bronchiolitis obliterans in the adult patient is a relatively uncommon and vexing clinical entity. This confusion results because this pathologic finding occurs in a variety of diverse clinical settings.
King, TE
core