Results 11 to 20 of about 10,536,235 (262)

Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

Frontiers in Immunology, 2021
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).
C. Schinocca, C. Rizzo, S. Fasano, G. Grasso, L. La Barbera, F. Ciccia, G. Guggino   +6 more
semanticscholar   +1 more source

Autoimmune Rheumatic Diseases [PDF]

BioMed Research International, 2014
The term autoimmune rheumatic diseases (ARDs) encompasses a heterogeneous group of conditions characterized by joint involvement along with a wide spectrum of systemic manifestations. The most common ARDs are rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Nevertheless, all these conditions share similar pathophysiological mechanisms [
Anaya, Juan Manuel, Shoenfeld, Yehuda, Buttgereit, Frank, González-Gay Mantecón, Miguel Ángel   +3 more
openaire   +5 more sources

COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations

Nature Reviews Rheumatology, 2022
The COVID-19 pandemic has brought challenges for people with rheumatic disease in addition to those faced by the general population, including concerns about higher risks of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ...
R. Grainger, A. Kim, R. Conway, J. Yazdany, P. Robinson   +4 more
semanticscholar   +1 more source

Glycobiology of rheumatic diseases

Nature Reviews Rheumatology, 2022
Autoantigen-specific IgG in patients with rheumatic diseases has a distinct N-glycosylation signature in the fragment crystallizable (Fc) domain, characterized by fucosylation without sialylation or galactosylation.
T. Kissel, R. Toes, T. Huizinga, M. Wuhrer   +3 more
semanticscholar   +1 more source

Increased risk of herpes zoster with tofacitinib treatment in Korean patients with rheumatoid arthritis: a single-center prospective study

Scientific Reports, 2023
We aimed to determine the risk of herpes zoster (HZ) in Korean rheumatoid arthritis (RA) patients on tofacitinib compared with tumor necrosis factor inhibitor (TNFi) treatment.
Yeo-Jin Song, Soo-Kyung Cho, Hyoungyoung Kim, Hye Won Kim, Eunwoo Nam, Ja-Young Jeon, Hyun-Jeong Yoo, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Sang-Cheol Bae, Dae Hyun Yoo, Yoon-Kyoung Sung   +12 more
doaj   +1 more source

Elderly onset atypical Lemierre’s syndrome concurrent with a rheumatoid vasculitis sacral ulcer infection: a case report

BMC Infectious Diseases, 2023
Background Typical Lemierre’s syndrome is usually secondary to an oropharyngeal infection. Recently, several cases following a primary infection site other than the oropharynx have been reported as atypical Lemierre’s syndrome; although, these primary ...
Koji Mishima, Kazunobu Aoki, Yusuke Shirai, Hiroshi Aritomo, Maiko Iwasaka, Masakazu Katsura, Tomofumi Tatsutani, Hiroko Ikeuchi, Kensuke Oryoji, Shinichi Mizuki   +9 more
doaj   +1 more source

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases

Frontiers in Immunology, 2021
Regulatory T cells (Treg) are crucial for the maintenance of peripheral tolerance and for the control of ongoing inflammation and autoimmunity. The cytokine interleukin-2 (IL-2) is essentially required for the growth and survival of Treg in the ...
H. Grasshoff, Sara Comdühr, Luisa R. Monne, A. Müller, P. Lamprecht, G. Riemekasten, J. Humrich   +6 more
semanticscholar   +1 more source

Disease activity and humoral response in patients with inflammatory rheumatic diseases after two doses of the Pfizer mRNA vaccine against SARS-CoV-2

Annals of the Rheumatic Diseases, 2021
Background The registration trials of messenger RNA (mRNA) vaccines against SARS-CoV-2 did not address patients with inflammatory rheumatic diseases (IRD).
Y. Braun-Moscovici, M. Kaplan, Maya Braun, D. Markovits, S. Giryes, K. Toledano, Y. Tavor, K. Dolnikov, A. Balbir-Gurman   +8 more
semanticscholar   +1 more source

IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes

Arthritis Research & Therapy, 2020
Background Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope.
Toshiyuki Ota, Shun-ichiro Ota, Ayumi Uchino, Shuji Nagano   +3 more
doaj   +1 more source

Enabling personal recovery from fibromyalgia – theoretical rationale, content and meaning of a person-centred, recovery-oriented programme

BMC Health Services Research, 2021
Background Fibromyalgia (FM) is a contested, chronic widespread pain syndrome on which recommended therapies have short-lasting, moderate effects. Nevertheless, some patients become symptom-free, and their recovery experiences inspired us to develop a ...
Anne Marit Mengshoel, Åse Skarbø, Elisabeth Hasselknippe, Tamara Petterson, Nina Linnea Brandsar, Ellen Askmann, Ragnhild Ildstad, Lena Løseth, Merja Helena Sallinen   +8 more
doaj   +1 more source