Results 111 to 120 of about 184,125 (352)

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Genetics of rheumatic fever and rheumatic heart disease

Nature Reviews Cardiology, 2019
Rheumatic heart disease (RHD) is a complication of group A streptococcal infection that results from a complex interaction between the genetic make-up of the host, the infection itself and several other environmental factors, largely reflecting poverty.
Babu Muhamed, Tom Parks, Karen Sliwa
openaire   +5 more sources

Cell Contractile Force‐Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds

Advanced Science, EarlyView.
Through the actuation of cell contractile forces, geometrically complex structures are formed via a bioprinted, rapidly degrading cell‐laden hydrogel system, resulting in cell‐only condensation within a few days of culture. This system supports stem cell differentiation down different lineages and new tissue formation, such as chondrogenesis and ...
Aixiang Ding, Kaelyn L. Gasvoda, David S. Cleveland, Sriramya Ayyagari, Eben Alsberg   +4 more
wiley   +1 more source

A predominance of hypertensive heart disease among patients with cardiac disease in Buea, a semi-urban setting, South West Region of Cameroon

BMC Research Notes, 2017
Objective The pattern of heart disease is diverse within and among world regions. The little data on the spectrum of heart disease in Cameroon has been so far limited to major cities.
Clovis Nkoke, Christelle Makoge, Anastase Dzudie, Liliane Kuate Mfeukeu, Engelbert Bain Luchuo, Alain Menanga, Samuel Kingue   +6 more
doaj   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Understanding the Twentieth Century Decline in Chronic Conditions Among Older Men [PDF]

I use a sample of Union Army veterans to trace the impact of a high infant mortality rate in area of enlistment, such infectious disease as acute respiratory infections, measles, typhoid fever, tuberculosis, rheumatic fever, diarrhea, and malaria while ...
Dora L. Costa
core  

Modest leucine supplement for prevention of rheumatic heart disease [PDF]

, 2018
Zi‐Wei Ye, Jingli Peng, Yue Du, Shanshan An, Qiuyun Liu   +4 more
openalex   +1 more source

THE DEGREE OF MANIFESTATION OF RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE IN PATIENTS

, 2022
Kholzhigitova Muhayo Berdikulovna, Ziyadullayeva Diyora   +1 more
openalex   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

RHD elimination: action needed beyond secondary prophylaxis

Australian and New Zealand Journal of Public Health, 2020
Kate Hardie, Anna P. Ralph, Jessica L. deDassel   +2 more
doaj   +1 more source