Results 111 to 120 of about 927,717 (352)

Rheumatic heart disease in the modern era: recent developments and current challenges.

Revista da Sociedade Brasileira de Medicina Tropical, 2019
Rheumatic heart disease (RHD) remains a major cause of preventable death and disability in children and young adults. Despite significant advances in medical technology and increased understanding of disease mechanisms, RHD continues to be a serious ...
Matheus Tozatto Baptista Coelho Leal, L. Passos, Felipe Vieira Guarçoni, J. Aguiar, Rafael Benjamim Rosa da Silva, Thiago Mendonça Nunes de Paula, Rafael Figueiredo Dos Santos, M. C. L. Nassif, N. F. A. Gomes, T. Tan, M. C. Nunes   +10 more
semanticscholar   +1 more source

Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes

Drugs in R&D
Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis.
Usman Nakakana, Alimamy Serry-Bangura, Bassey Effiom Edem, Pietro Tessitore, Leonardo Di Cesare, Danilo Gomes Moriel, Audino Podda, Iris Sarah De Ryck, Ashwani Kumar Arora   +8 more
doaj   +1 more source

How Many Doses Make a Difference? An Analysis of Secondary Prevention of Rheumatic Fever and Rheumatic Heart Disease

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background Acute rheumatic fever (ARF) and rheumatic heart disease cause substantial burdens worldwide. Long‐term antibiotic secondary prophylaxis is used to prevent disease progression, but evidence for benefits of different adherence levels is limited.
J. D. de Dassel, N. de Klerk, J. Carapetis, A. Ralph   +3 more
semanticscholar   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

A Modular Perfusion Bioreactor Platform for Simulating Bone Regeneration and Fracture Healing: Integrating Mechanical Loading and Dual Perfusion for Advanced In Vitro Models

Advanced Healthcare Materials, EarlyView.
A modular bioreactor platform was developed in order to replicate bone homeostasis and pathology, thereby integrating mechanical loading, dynamic perfusion, and a 3D‐printed microfluidic chamber. With precise control of environmental parameters and dual perfusion for composite tissue models, the system enhances physiological relevance for studying bone
Moritz Pfeiffenberger, Alexandra Damerau, Johannes Plank, Adel Ahmed, Mario Thiele, Jan Saam, Paula Hoff, Timo Gaber, Frank Buttgereit   +8 more
wiley   +1 more source

Biodegradable Implantable Electronics with Wireless Technology for Real‐Time Clinical Applications

Advanced Healthcare Materials, EarlyView.
The article explores how bioresorbable implantable electronics merge wireless communication and power delivery with biodegradable materials to enable real‐time clinical applications. It highlights advances in materials, system design, and medical uses across neural, cardiovascular, digestive, immune, and drug‐delivery systems.
Myeongki Cho, Jeong Woo Chae, Young‐Jin Park, Ki Jun Yu, Sang Min Won   +4 more
wiley   +1 more source

The burden of rheumatic heart disease among children in Lagos: how are we faring?

The Pan African Medical Journal, 2018
INTRODUCTION: Rheumatic heart disease still remains a cause of morbidity and mortality in low and middle income countries, despite its eradication in developed societies.
Barakat Adeola Animasahun, Akpoembele Deborah Madise Wobo, Adejumoke Yemisi Itiola, Motunrayo Oluwabukola Adekunle, Olusola Yejide Kusimo, Fidelia Bode Thomas   +5 more
doaj   +1 more source

Acute Jaundice in a Six-year-old: An Unusual Presentation of Atypical Kawasaki Disease [PDF]

, 2020
Kawasaki disease (KD) is a rare vasculitis of childhood that is critical to recognize and treat due to associated morbidity and mortality. A six-year-old male presented to our emergency department (ED) afebrile but with reported recent fevers.
Bylund, LCDR William, Morrison Ponce, LCDR Daphne, Zarow, Gregory J.   +2 more
core  

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Nature Communications, 2017
The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying
T. Parks, M. Mirabel, J. Kado, K. Auckland, Jaroslaw Nowak, A. Rautanen, A. Mentzer, É. Marijon, X. Jouven, Mai Ling Perman, Tuliana Cua, J. Kauwe, John B. Allen, Henry Taylor, K. Robson, C. Deane, A. Steer, A. Hill, Lori Marvin Corinne Samantha M. Aurélia Maureen Rina Wi Allen Allen Braunstein Colquhoun Jewine Ah Kee Kum, Lori B. Allen, M. Allen, C. Braunstein, Samantha M. Colquhoun, Aurélia Jewine, Maureen Ah Kee, R. Kumar, W. John Martin, Reapi L. Mataika, M. Nadra, Shahin Nadu, T. Naseri, B. Noël, Nathalie Simon, Brenton Ward   +33 more
semanticscholar   +1 more source

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source