Results 121 to 130 of about 6,012,951 (335)

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

RHEUMATIC HEART DISEASE IN THE SUDAN [PDF]

Heart, 1961
A M, HALIM, J E, JACQUES
openaire   +2 more sources

Preventive interventions to reduce the burden of rheumatic heart disease in populations at risk : a systematic review

BACKGROUND: Rheumatic heart disease (RHD) is a devastating yet preventable condition that disproportionately affects low-middle-income countries and indigenous populations in some high-income countries.
Panduleni Penipawa Shimanda, Lindholm, Lars, Norström, Fredrik, Scholastika N. Iipinge, Lars Lindholm, Brunström, Mattias,, Shimanda, Panduleni Penipawa, Tonderai W. Shumba, Mattias Brunström, Stefan Söderberg, Shumba, Tonderai W,, Brunström, Mattias, Shimanda, Panduleni Penipawa,, Norström, Fredrik,, Shumba, Tonderai W, Lindholm, Lars,, Iipinge, Scholastika N, Iipinge, Scholastika N,, Söderberg, Stefan,, Söderberg, Stefan, Fredrik Norström   +20 more
core   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

AWARENESS OF RHEUMATIC HEART DISEASE IN PATIENTS SUFFERING FROM RHEUMATIC HEART DISEASE

Journal of University Medical & Dental College, 2016
: OBJECTIVE: To determine the degree of awareness about the different aspects of rheumatic heart disease in patients coming to different departments of Faisalabad Institute of Cardiology, Faisalabad. STUDY DESIGN AND DURATION: Questionnaire based survey
M Hamid Saeed1, Muhammad Shahzad Afzal
doaj  

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Practice and clinical outcomes of valvular surgery for rheumatic heart disease in africa: a scoping review

Journal of Cardiothoracic Surgery
Background Rheumatic heart disease is prevalent in Africa, but advanced cardiac care for the condition, which includes valve surgery, is limited. This study examined rheumatic heart disease surgical management and clinical outcomes in Africa.
Victor Oluwafemi Femi-Lawal, Victory Bassey Effiom, Anayo James Michael, Joy Nsa Ekpenyong, Ekene Nwajei, Achanga Bill-Smith Anyinkeng, Shubh Ketan Patel, Kevin R. An, Kelechi E. Okonta   +8 more
doaj   +1 more source

Rheumatic Heart Disease Burden

JACC: Advances
Background: Rheumatic heart disease (RHD) is a major challenge to global health, primarily in low- and middle-income countries. Even though RHD is rare in high-income countries, it still poses a health challenge, yet there is a lack of data on its impact
Stefan Milutinovic, MD, Marija Petrovic, MD, PhD, Aya Ziq, MS, Christian Sanchez, BS, Ahmed Sami Hammami, MD, Ricardo Orlando Escarcega, MD, Dustin Begosh-Mayne, MD, Malissa J. Wood, MD, Richard A. Chazal, MD, Juan C. Lopez-Mattei, MD   +9 more
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source